Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/HTH_10(toxin)
Location 1932053..1933032 Replicon chromosome
Accession NZ_CP077713
Organism Saccharolobus shibatae strain S38A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U22_RS10270 Protein ID WP_218258149.1
Coordinates 1932418..1933032 (+) Length 205 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U22_RS10265 Protein ID WP_218260273.1
Coordinates 1932053..1932400 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U22_RS10235 (J5U22_02170) 1928087..1928662 + 576 Protein_2059 IS5/IS1182 family transposase -
J5U22_RS10240 (J5U22_02171) 1928699..1929643 - 945 WP_218258146.1 IS110 family transposase -
J5U22_RS10245 (J5U22_02172) 1929802..1930188 + 387 Protein_2061 IS5/IS1182 family transposase -
J5U22_RS10250 (J5U22_02173) 1930851..1931282 + 432 WP_218258147.1 universal stress protein -
J5U22_RS10255 (J5U22_02174) 1931275..1931658 - 384 WP_218258148.1 metal-sulfur cluster assembly factor -
J5U22_RS10260 (J5U22_02175) 1931706..1931981 + 276 WP_261310045.1 hypothetical protein -
J5U22_RS10265 (J5U22_02176) 1932053..1932400 + 348 WP_218260273.1 DUF488 domain-containing protein Antitoxin
J5U22_RS10270 (J5U22_02177) 1932418..1933032 + 615 WP_218258149.1 helix-turn-helix domain-containing protein Toxin
J5U22_RS10275 (J5U22_02178) 1933077..1933352 - 276 WP_218258150.1 hypothetical protein -
J5U22_RS10280 (J5U22_02179) 1933501..1934004 + 504 WP_261310046.1 hemerythrin domain-containing protein -
J5U22_RS10285 (J5U22_02180) 1934109..1934855 + 747 WP_218258152.1 plastocyanin/azurin family copper-binding protein -
J5U22_RS10290 (J5U22_02181) 1934859..1935182 + 324 WP_218258153.1 hypothetical protein -
J5U22_RS10295 1935163..1935390 - 228 WP_218258154.1 hypothetical protein -
J5U22_RS10300 (J5U22_02182) 1935638..1936237 + 600 WP_218258155.1 DUF2249 domain-containing protein -
J5U22_RS10305 1936507..1937766 + 1260 Protein_2073 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterioopsin activator-type, HTH domain

(145-197)

Antitoxin

Protein of unknown function DUF488

(3-108)


Sequences

Toxin        


Download         Length: 205 a.a.        Molecular weight: 23212.23 Da        Isoelectric Point: 9.2823

>T207662 WP_218258149.1 NZ_CP077713:1932418-1933032 [Saccharolobus shibatae]
MLKSPFEVTILIEEHPCEVMRIISSTGLKATVDNVKLGDNATDHIVLFEKEVQKDDLIKLKSHSTKVLKLNDSKVWVRTN
GCSVCKILYTSNVVVEKIKVVKERTLLYTLLVPNTIAFKEFLANLTSQGIKFTVLNTSEISSNDLTDRQMEILKLAYKMG
YFDDDRRVTLTELAKQLGISAPTLEEIMRRALRKVVKYYLDKVG

Download         Length: 615 bp

>T207662 NZ_CP103468:224678-224785 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13720.03 Da        Isoelectric Point: 10.0168

>AT207662 WP_218260273.1 NZ_CP077713:1932053-1932400 [Saccharolobus shibatae]
MIKIKRVYDPIEKDDGIRILVDRLWPRGIGKNKVDLWLKDIAPSDELRRWYGHDASKWDEFKRKYFEELDANPKMSILLQ
LIRKGENITLLYASKSPYNNAIALKEYLEKKILKQ

Download         Length: 348 bp

>AT207662 NZ_CP103468:c224621-224566 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References