Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1510566..1511172 Replicon chromosome
Accession NZ_CP077713
Organism Saccharolobus shibatae strain S38A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5U22_RS08040 Protein ID WP_218257805.1
Coordinates 1510566..1510958 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5U22_RS08045 Protein ID WP_218257806.1
Coordinates 1510948..1511172 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5U22_RS08020 (J5U22_01674) 1505800..1506210 + 411 WP_218257801.1 hypothetical protein -
J5U22_RS08025 (J5U22_01675) 1506215..1507171 + 957 WP_218257802.1 type III-A CRISPR-associated RAMP protein Csm3 -
J5U22_RS08030 (J5U22_01676) 1507168..1508178 + 1011 WP_218257803.1 type III-A CRISPR-associated RAMP protein Csm5 -
J5U22_RS08035 (J5U22_01677) 1508185..1510527 + 2343 WP_218257804.1 hydrolase -
J5U22_RS08040 (J5U22_01678) 1510566..1510958 - 393 WP_218257805.1 type II toxin-antitoxin system VapC family toxin Toxin
J5U22_RS08045 (J5U22_01679) 1510948..1511172 - 225 WP_218257806.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J5U22_RS08050 (J5U22_01680) 1512069..1512386 - 318 WP_218257807.1 clan AA aspartic protease -
J5U22_RS08055 (J5U22_01681) 1512376..1513341 - 966 WP_218257808.1 CRISPR system ring nuclease -
J5U22_RS15495 (J5U22_01682) 1514039..1514200 - 162 WP_261310003.1 hypothetical protein -
J5U22_RS15500 (J5U22_01683) 1514381..1514668 - 288 WP_261310004.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1515095..1516324 1229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(8-124)

Antitoxin

Putative antitoxin VapB3-like

(1-74)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 15128.84 Da        Isoelectric Point: 9.0292

>T207661 WP_218257805.1 NZ_CP077713:c1510958-1510566 [Saccharolobus shibatae]
MKDKEFLLDASALYSLLDYVDKVDVKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Download         Length: 393 bp

>T207661 NZ_CP103468:224194-224301 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8787.12 Da        Isoelectric Point: 5.0355

>AT207661 WP_218257806.1 NZ_CP077713:c1511172-1510948 [Saccharolobus shibatae]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIKEKEKEELKDTAMKIKELMRDVSEDDWVRTVRESRDER

Download         Length: 225 bp

>AT207661 NZ_CP103468:c224145-224082 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References