Detailed information of TA system TA207661

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-CcdA
• Location: 1510566..1511172
• Replicon: chromosome
• Accession: NZ_CP077713
• Organism: Saccharolobus shibatae strain S38A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5U22_RS08040
• Protein ID: WP_218257805.1
• Coordinates: 1510566..1510958 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J5U22_RS08045
• Protein ID: WP_218257806.1
• Coordinates: 1510948..1511172 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5U22_RS08020 (J5U22_01674)	1505800..1506210	+	411	WP_218257801.1	hypothetical protein	-
J5U22_RS08025 (J5U22_01675)	1506215..1507171	+	957	WP_218257802.1	type III-A CRISPR-associated RAMP protein Csm3	-
J5U22_RS08030 (J5U22_01676)	1507168..1508178	+	1011	WP_218257803.1	type III-A CRISPR-associated RAMP protein Csm5	-
J5U22_RS08035 (J5U22_01677)	1508185..1510527	+	2343	WP_218257804.1	hydrolase	-
J5U22_RS08040 (J5U22_01678)	1510566..1510958	-	393	WP_218257805.1	type II toxin-antitoxin system VapC family toxin	Toxin
J5U22_RS08045 (J5U22_01679)	1510948..1511172	-	225	WP_218257806.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
J5U22_RS08050 (J5U22_01680)	1512069..1512386	-	318	WP_218257807.1	clan AA aspartic protease	-
J5U22_RS08055 (J5U22_01681)	1512376..1513341	-	966	WP_218257808.1	CRISPR system ring nuclease	-
J5U22_RS15495 (J5U22_01682)	1514039..1514200	-	162	WP_261310003.1	hypothetical protein	-
J5U22_RS15500 (J5U22_01683)	1514381..1514668	-	288	WP_261310004.1	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1515095..1516324	1229

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Pae0151-like, PIN domain (8-124)

Antitoxin

• Putative antitoxin VapB3-like (1-74)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 15128.84 Da
• Isoelectric Point: 9.0292

>T207661 WP_218257805.1 NZ_CP077713:c1510958-1510566 [Saccharolobus shibatae]
MKDKEFLLDASALYSLLDYVDKVDVKKIHILTLTFYEVGNVIWKEYYIHKKVKDPITLSRLFYKLMRKFNVVEDPPLEGV
MRIAIERGLTYYDASYAYVAESLGLILVSNDKELIRKANAISLKDLIKSM

Nucleotide

• Length: 393 bp

>T207661 NZ_CP103468:224194-224301 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8787.12 Da
• Isoelectric Point: 5.0355

>AT207661 WP_218257806.1 NZ_CP077713:c1511172-1510948 [Saccharolobus shibatae]
MSDVISVRVKKELKKKAEELGINIREVVEKALEEAIKEKEKEELKDTAMKIKELMRDVSEDDWVRTVRESRDER

Nucleotide

• Length: 225 bp

>AT207661 NZ_CP103468:c224145-224082 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT