Detailed information of TA system TA020766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 179701..180217
• Replicon: chromosome
• Accession: NC_004129
• Organism: Pseudomonas protegens Pf-5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F9XXF1
• Locus tag: PFL_RS00790
• Protein ID: WP_011058535.1
• Coordinates: 179936..180217 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q4KKD3
• Locus tag: PFL_RS00785
• Protein ID: WP_011058534.1
• Coordinates: 179701..179946 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PFL_RS00770	177195..178805	+	1611	WP_011058531.1	glycosyltransferase family 39 protein	-
PFL_RS00775	178915..179376	+	462	WP_011058532.1	YbaK/EbsC family protein	-
PFL_RS00780	179391..179636	+	246	WP_011058533.1	DUF2789 domain-containing protein	-
PFL_RS00785	179701..179946	+	246	WP_011058534.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
PFL_RS00790	179936..180217	+	282	WP_011058535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PFL_RS00795	180360..180788	+	429	WP_011058536.1	winged helix DNA-binding protein	-
PFL_RS00800	180785..182872	+	2088	WP_011058537.1	FUSC family protein	-
PFL_RS00805	182869..183078	+	210	WP_011058538.1	DUF1656 domain-containing protein	-
PFL_RS00810	183075..183965	+	891	WP_011058539.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-69)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10839.72 Da
• Isoelectric Point: 10.2298

>T20766 WP_011058535.1 NC_004129:179936-180217 [Pseudomonas protegens Pf-5]
MTYSLEFLPSAHKEWNKLGHTLREQFKKKLAERLEVPRIPADALHGLPDCYKIKLKASGYRLVYQVIEERVVVCVVAVGK
RERGTVYEQARKR

Nucleotide

• Length: 282 bp

>T20766 NC_004129:179936-180217 [Pseudomonas protegens Pf-5]
ATGACTTATAGCCTTGAGTTCCTGCCTTCGGCACACAAGGAATGGAACAAGTTGGGGCATACGCTTCGAGAGCAATTCAA
GAAAAAGCTCGCCGAACGGCTTGAGGTGCCGCGAATCCCTGCTGATGCCCTGCATGGGCTTCCCGATTGCTACAAAATTA
AACTCAAGGCTTCGGGCTACCGATTGGTTTATCAAGTGATCGAAGAGCGCGTCGTGGTTTGCGTGGTTGCGGTCGGCAAG
CGCGAGCGTGGAACCGTTTACGAGCAGGCCAGGAAACGCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8799.10 Da
• Isoelectric Point: 4.3988

>AT20766 WP_011058534.1 NC_004129:179701-179946 [Pseudomonas protegens Pf-5]
MQSILADKAVSVSELKKNPSAVLSGAQGGPVAVLNHNRVMGYMVPAEVFEALMERLDDLELAEIIRERSHETPVPVSLDD
L

Nucleotide

• Length: 246 bp

>AT20766 NC_004129:179701-179946 [Pseudomonas protegens Pf-5]
ATGCAGAGTATTCTGGCTGACAAAGCCGTCAGCGTATCTGAGTTGAAGAAAAACCCTTCTGCCGTCTTGAGTGGTGCCCA
GGGCGGGCCAGTGGCGGTGTTGAATCACAATCGTGTCATGGGCTACATGGTTCCGGCCGAGGTTTTCGAAGCGTTGATGG
AACGCCTGGATGATCTGGAGTTGGCCGAAATCATCCGCGAGCGCAGCCATGAGACGCCCGTTCCGGTCAGTCTGGATGAC
TTATAG

Structures

Toxin

• AlphaFold DB: F9XXF1

Antitoxin

• AlphaFold DB: Q4KKD3