Detailed information of TA system TA207659

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-AbrB
• Location: 1241914..1242526
• Replicon: chromosome
• Accession: NZ_CP077713
• Organism: Saccharolobus shibatae strain S38A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J5U22_RS06705
• Protein ID: WP_218260057.1
• Coordinates: 1242134..1242526 (+)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J5U22_RS06700
• Protein ID: WP_218260056.1
• Coordinates: 1241914..1242147 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5U22_RS06675 (J5U22_01368)	1238172..1238378	+	207	WP_218260051.1	hypothetical protein	-
J5U22_RS06680 (J5U22_01369)	1238678..1239757	+	1080	WP_218260052.1	transposase	-
J5U22_RS06685 (J5U22_01370)	1239912..1240100	-	189	WP_218260053.1	hypothetical protein	-
J5U22_RS06690 (J5U22_01371)	1240313..1241011	+	699	WP_218260054.1	TIGR00266 family protein	-
J5U22_RS15410 (J5U22_01372)	1241323..1241578	+	256	Protein_1335	hypothetical protein	-
J5U22_RS06700 (J5U22_01373)	1241914..1242147	+	234	WP_218260056.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J5U22_RS06705 (J5U22_01374)	1242134..1242526	+	393	WP_218260057.1	PIN domain-containing protein	Toxin
J5U22_RS06710 (J5U22_01375)	1243079..1243600	+	522	WP_218260058.1	hypothetical protein	-
J5U22_RS06715 (J5U22_01376)	1243923..1244351	+	429	WP_218260059.1	HEPN domain-containing protein	-
J5U22_RS06720 (J5U22_01377)	1244314..1244754	+	441	WP_218260060.1	nucleotidyltransferase domain-containing protein	-
J5U22_RS15415 (J5U22_01378)	1245170..1245304	-	135	Protein_1341	transposase	-
J5U22_RS06725 (J5U22_01379)	1245540..1245770	+	231	WP_218260061.1	CopG family transcriptional regulator	-
J5U22_RS15420	1245767..1245919	+	153	WP_261310121.1	hypothetical protein	-
J5U22_RS15425 (J5U22_01380)	1245876..1246127	+	252	WP_261310122.1	type II toxin-antitoxin system VapC family toxin	-
J5U22_RS06735 (J5U22_01381)	1246248..1246484	+	237	WP_218260062.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
J5U22_RS15430 (J5U22_01382)	1246949..1247257	-	309	WP_261310123.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1238678..1239757	1079

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14914.37 Da
• Isoelectric Point: 4.5837

>T207659 WP_218260057.1 NZ_CP077713:1242134-1242526 [Saccharolobus shibatae]
MIVVDTNVLVYATFEDSKYHKESVNIIQREDVIIPQIVVYEYLEVLSELVPDLNFVKTKTEELTEFNIVCEDMNIILQAI
NLIKNTKLSLKNINDFIILSFSLYTKSSLATFDVKLRKLAEKNGVNVLPS

Nucleotide

• Length: 393 bp

>T207659 NZ_CP103468:166866-167051 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 9000.32 Da
• Isoelectric Point: 6.3727

>AT207659 WP_218260056.1 NZ_CP077713:1241914-1242147 [Saccharolobus shibatae]
MKRNVSKVTRNYQLTIPLEIREFLGIKEGEYVEFEIDDGKVVIKPLRKKWSTVKLRKQVSVEEIEEIANSAFENDSS

Nucleotide

• Length: 234 bp

>AT207659 NZ_CP103468:167068-167478 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGCCGCGCACTTCGAAACCTTATGCGAGATGG
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA