Detailed information of TA system TA207657

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 4701625..4702241
• Replicon: chromosome
• Accession: NZ_CP077711
• Organism: Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A3Z6QPG7
• Locus tag: DAX63_RS22835
• Protein ID: WP_000238496.1
• Coordinates: 4701625..4701999 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: DAX63_RS22840
• Protein ID: WP_001523745.1
• Coordinates: 4701999..4702241 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX63_RS22820 (4699127)	4699127..4700029	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
DAX63_RS22825 (4700026)	4700026..4700661	+	636	WP_108429743.1	formate dehydrogenase cytochrome b556 subunit	-
DAX63_RS22830 (4700658)	4700658..4701587	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
DAX63_RS22835 (4701625)	4701625..4701999	-	375	WP_000238496.1	type II toxin-antitoxin system VapC family toxin	Toxin
DAX63_RS22840 (4701999)	4701999..4702241	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
DAX63_RS22845 (4702446)	4702446..4703375	+	930	WP_001162863.1	alpha/beta hydrolase fold domain-containing protein	-
DAX63_RS22850 (4703461)	4703461..4703772	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DAX63_RS22855 (4703769)	4703769..4704215	+	447	WP_001259012.1	type II toxin-antitoxin system HigA family antitoxin	-
DAX63_RS22860 (4704230)	4704230..4705171	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
DAX63_RS22865 (4705216)	4705216..4705653	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
DAX63_RS22870 (4705650)	4705650..4706522	-	873	WP_000921423.1	virulence factor BrkB family protein	-
DAX63_RS22875 (4706516)	4706516..4707115	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-115)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13936.24 Da
• Isoelectric Point: 8.0689

>T207657 WP_000238496.1 NZ_CP077711:c4701999-4701625 [Salmonella enterica subsp. enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPRNAISLITWMEVMVGAKKYHQENRTRIALSAFNIIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFADIPGVITPYHL

Nucleotide

• Length: 375 bp

>T207657 NZ_CP103466:c110345-109965 [Escherichia coli O25b:H4-ST131]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT207657 WP_001523745.1 NZ_CP077711:c4702241-4701999 [Salmonella enterica subsp. enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT207657 NZ_CP103466:c110566-110345 [Escherichia coli O25b:H4-ST131]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A3Z6QPG7