Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4272403..4272919 Replicon chromosome
Accession NZ_CP077711
Organism Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAX63_RS20845 Protein ID WP_000220578.1
Coordinates 4272403..4272687 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DAX63_RS20850 Protein ID WP_000212724.1
Coordinates 4272677..4272919 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX63_RS20830 (4267615) 4267615..4269267 + 1653 WP_000155056.1 alpha,alpha-phosphotrehalase -
DAX63_RS20835 (4269676) 4269676..4271814 + 2139 WP_000187822.1 anaerobic ribonucleoside-triphosphate reductase -
DAX63_RS20840 (4271935) 4271935..4272399 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX63_RS20845 (4272403) 4272403..4272687 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX63_RS20850 (4272677) 4272677..4272919 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX63_RS20855 (4272997) 4272997..4274910 - 1914 WP_023240628.1 BglG family transcription antiterminator -
DAX63_RS20860 (4274927) 4274927..4275667 - 741 WP_000779252.1 KDGP aldolase family protein -
DAX63_RS20865 (4275664) 4275664..4276782 - 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX63_RS20870 (4276766) 4276766..4277899 - 1134 WP_000459948.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207656 WP_000220578.1 NZ_CP077711:c4272687-4272403 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207656 NZ_CP103466:34679-34828 [Escherichia coli O25b:H4-ST131]
ATGACGAAGTATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207656 WP_000212724.1 NZ_CP077711:c4272919-4272677 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207656 NZ_CP103466:c34634-34575 [Escherichia coli O25b:H4-ST131]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References