Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4178493..4179069 Replicon chromosome
Accession NZ_CP077711
Organism Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag DAX63_RS20405 Protein ID WP_001131963.1
Coordinates 4178782..4179069 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag DAX63_RS20400 Protein ID WP_000063142.1
Coordinates 4178493..4178795 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX63_RS20385 (4175003) 4175003..4177153 + 2151 WP_000379928.1 pyruvate/proton symporter BtsT -
DAX63_RS20390 (4177248) 4177248..4177451 + 204 WP_000460616.1 YbdD/YjiX family protein -
DAX63_RS20395 (4177462) 4177462..4178418 + 957 WP_000187838.1 GTPase -
DAX63_RS20400 (4178493) 4178493..4178795 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
DAX63_RS20405 (4178782) 4178782..4179069 - 288 WP_001131963.1 BrnT family toxin Toxin
DAX63_RS20410 (4179338) 4179338..4180252 - 915 WP_023240766.1 restriction endonuclease -
DAX63_RS20415 (4180450) 4180450..4183959 + 3510 WP_023240765.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T207655 WP_001131963.1 NZ_CP077711:c4179069-4178782 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

>T207655 NZ_CP103465:c4253094-4252921 [Escherichia coli O25b:H4-ST131]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT207655 WP_000063142.1 NZ_CP077711:c4178795-4178493 [Salmonella enterica subsp. enterica]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp

>AT207655 NZ_CP103465:c4253418-4253122 [Escherichia coli O25b:H4-ST131]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References