Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 944059..944719 Replicon chromosome
Accession NZ_CP077711
Organism Salmonella enterica subsp. enterica strain CFSAN058606

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Z4W5P7
Locus tag DAX63_RS04620 Protein ID WP_023238814.1
Coordinates 944306..944719 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAX63_RS04615 Protein ID WP_000351186.1
Coordinates 944059..944325 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX63_RS04595 (939996) 939996..941429 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
DAX63_RS04600 (941587) 941587..941898 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
DAX63_RS04605 (942062) 942062..942721 + 660 WP_000250289.1 hemolysin III family protein -
DAX63_RS04610 (942829) 942829..943809 - 981 WP_047643392.1 tRNA-modifying protein YgfZ -
DAX63_RS04615 (944059) 944059..944325 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAX63_RS04620 (944306) 944306..944719 + 414 WP_023238814.1 protein YgfX Toxin
DAX63_RS04625 (944772) 944772..945293 - 522 WP_001055885.1 flavodoxin FldB -
DAX63_RS04630 (945406) 945406..946302 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DAX63_RS04635 (946326) 946326..947039 + 714 WP_000745624.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAX63_RS04640 (947045) 947045..948778 + 1734 WP_000813381.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16130.10 Da        Isoelectric Point: 9.4814

>T207640 WP_023238814.1 NZ_CP077711:944306-944719 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGCLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207640 NZ_CP103465:c805287-804910 [Escherichia coli O25b:H4-ST131]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207640 WP_000351186.1 NZ_CP077711:944059-944325 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207640 NZ_CP103465:c805744-805376 [Escherichia coli O25b:H4-ST131]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z4W5P7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References