Detailed information of TA system TA207637

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1(toxin)
• Location: 5033065..5033681
• Replicon: chromosome
• Accession: NZ_CP077710
• Organism: Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E9YCX3
• Locus tag: DAX88_RS23975
• Protein ID: WP_023249114.1
• Coordinates: 5033065..5033439 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E9YHE9
• Locus tag: DAX88_RS23980
• Protein ID: WP_001523745.1
• Coordinates: 5033439..5033681 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX88_RS23960 (5030567)	5030567..5031469	+	903	WP_070789960.1	formate dehydrogenase subunit beta	-
DAX88_RS23965 (5031466)	5031466..5032101	+	636	WP_000829028.1	formate dehydrogenase cytochrome b556 subunit	-
DAX88_RS23970 (5032098)	5032098..5033027	+	930	WP_023249115.1	formate dehydrogenase accessory protein FdhE	-
DAX88_RS23975 (5033065)	5033065..5033439	-	375	WP_023249114.1	type II toxin-antitoxin system VapC family toxin	Toxin
DAX88_RS23980 (5033439)	5033439..5033681	-	243	WP_001523745.1	CopG family transcriptional regulator	Antitoxin
DAX88_RS23985 (5033886)	5033886..5034812	+	927	Protein_4727	alpha/beta hydrolase	-
DAX88_RS23990 (5034898)	5034898..5035209	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
DAX88_RS23995 (5035206)	5035206..5035652	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
DAX88_RS24000 (5035667)	5035667..5036608	-	942	WP_024134888.1	fatty acid biosynthesis protein FabY	-
DAX88_RS24005 (5036653)	5036653..5037090	-	438	WP_023249111.1	D-aminoacyl-tRNA deacylase	-
DAX88_RS24010 (5037087)	5037087..5037959	-	873	WP_023249110.1	virulence factor BrkB family protein	-
DAX88_RS24015 (5037953)	5037953..5038552	-	600	WP_023249109.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Ribbon-helix-helix protein, CopG (13-47)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13836.12 Da
• Isoelectric Point: 8.0689

>T207637 WP_023249114.1 NZ_CP077710:c5033439-5033065 [Salmonella enterica subsp. enterica]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNVIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFAGIPGVITPYHL

Nucleotide

• Length: 375 bp

>T207637 NZ_CP103465:c602513-602049 [Escherichia coli O25b:H4-ST131]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9437.77 Da
• Isoelectric Point: 4.4463

>AT207637 WP_001523745.1 NZ_CP077710:c5033681-5033439 [Salmonella enterica subsp. enterica]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Nucleotide

• Length: 243 bp

>AT207637 NZ_CP103465:c602848-602513 [Escherichia coli O25b:H4-ST131]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA