Detailed information of TA system TA207636

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 4710229..4710986
• Replicon: chromosome
• Accession: NZ_CP077710
• Organism: Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: DAX88_RS22645
• Protein ID: WP_023249556.1
• Coordinates: 4710504..4710986 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A5Y0S3F2
• Locus tag: DAX88_RS22640
• Protein ID: WP_001750501.1
• Coordinates: 4710229..4710513 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX88_RS22625 (4706422)	4706422..4708110	-	1689	WP_070789718.1	PilN family type IVB pilus formation outer membrane protein	-
DAX88_RS22630 (4708131)	4708131..4708568	-	438	WP_023249558.1	type IV pilus biogenesis protein PilM	-
DAX88_RS22635 (4708568)	4708568..4709842	-	1275	WP_044136653.1	TcpQ domain-containing protein	-
DAX88_RS22640 (4710229)	4710229..4710513	+	285	WP_001750501.1	DUF1778 domain-containing protein	Antitoxin
DAX88_RS22645 (4710504)	4710504..4710986	+	483	WP_023249556.1	GNAT family N-acetyltransferase	Toxin
DAX88_RS22650 (4711265)	4711265..4711660	-	396	WP_023249555.1	glyoxalase/bleomycin resistance protein/dioxygenase	-
DAX88_RS22655 (4711927)	4711927..4712328	-	402	WP_023249554.1	HD domain-containing protein	-
DAX88_RS22660 (4712457)	4712457..4712624	-	168	WP_170245768.1	hypothetical protein	-
DAX88_RS22665 (4712549)	4712549..4713317	+	769	Protein_4475	IS3 family transposase	-
DAX88_RS22670 (4714353)	4714353..4715201	-	849	WP_024149777.1	SdiA-regulated domain-containing protein	-
DAX88_RS22675 (4715315)	4715315..4715572	-	258	WP_023249551.1	FaeA/PapI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4713087..4713215	128

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-149)

Antitoxin

• Vibrio phage ICP1, Orf50 (13-87)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 17947.68 Da
• Isoelectric Point: 6.8355

>T207636 WP_023249556.1 NZ_CP077710:4710504-4710986 [Salmonella enterica subsp. enterica]
MEINVTAPELLNEEHILQSFDCGNDVLSDWLCRRAMKNQHLNASRTFVICLECTKRVVGYYSIATGSISHVDLGRSLRQN
MPDPVPVVLLGRLAIDKCTQGQNFGKWLLNDAVTRVSNLADQVGIKAIMVHAIDEQAKAFYEYFGFVQSPVAPNTLFYKI

Nucleotide

• Length: 483 bp

>T207636 NZ_CP103465:291053-291580 [Escherichia coli O25b:H4-ST131]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11033.58 Da
• Isoelectric Point: 8.5171

>AT207636 WP_001750501.1 NZ_CP077710:4710229-4710513 [Salmonella enterica subsp. enterica]
MQTTTRKSIRNKQINIRATDEERAVIDYAAKLVSKNRTDFIIEKAVNEAQNIILDQRVFVLDDARYQAFIEQLEAPVQNV
EGRQRLMDVKPEWK

Nucleotide

• Length: 285 bp

>AT207636 NZ_CP103465:290780-291046 [Escherichia coli O25b:H4-ST131]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A5Y0S3F2