Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4427316..4427832 Replicon chromosome
Accession NZ_CP077710
Organism Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)


Gene name relE Uniprot ID V1HEI0
Locus tag DAX88_RS21245 Protein ID WP_000220584.1
Coordinates 4427316..4427600 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V1HDU1
Locus tag DAX88_RS21250 Protein ID WP_023182636.1
Coordinates 4427590..4427832 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX88_RS21230 (4422457) 4422457..4424109 + 1653 WP_023248623.1 alpha,alpha-phosphotrehalase -
DAX88_RS21235 (4424519) 4424519..4426657 + 2139 WP_023248624.1 anaerobic ribonucleoside-triphosphate reductase -
DAX88_RS21240 (4426842) 4426842..4427306 + 465 WP_023248625.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX88_RS21245 (4427316) 4427316..4427600 - 285 WP_000220584.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX88_RS21250 (4427590) 4427590..4427832 - 243 WP_023182636.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX88_RS21255 (4427911) 4427911..4429824 - 1914 WP_023248626.1 BglG family transcription antiterminator -
DAX88_RS21260 (4429841) 4429841..4430581 - 741 WP_070790078.1 KDGP aldolase family protein -
DAX88_RS21265 (4430578) 4430578..4431696 - 1119 WP_023248628.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX88_RS21270 (4431680) 4431680..4432813 - 1134 WP_023248629.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11085.02 Da        Isoelectric Point: 10.3015

>T207635 WP_000220584.1 NZ_CP077710:c4427600-4427316 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKTSGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Download         Length: 285 bp

>T207635 NZ_CP103465:188542-188649 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9013.38 Da        Isoelectric Point: 5.0651

>AT207635 WP_023182636.1 NZ_CP077710:c4427832-4427590 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDALLQTVRERLANPQKGIRVSLDDL

Download         Length: 243 bp

>AT207635 NZ_CP103465:c188485-188428 [Escherichia coli O25b:H4-ST131]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A741MVA9

Antitoxin

Source ID Structure

References