Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4287040..4287616 Replicon chromosome
Accession NZ_CP077710
Organism Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)


Gene name shpA Uniprot ID A0A8E9YCK2
Locus tag DAX88_RS20565 Protein ID WP_023247536.1
Coordinates 4287329..4287616 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A8E9YD15
Locus tag DAX88_RS20560 Protein ID WP_023247535.1
Coordinates 4287040..4287342 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX88_RS20545 (4283550) 4283550..4285700 + 2151 WP_023247533.1 pyruvate/proton symporter BtsT -
DAX88_RS20550 (4285795) 4285795..4285998 + 204 WP_000460616.1 YbdD/YjiX family protein -
DAX88_RS20555 (4286009) 4286009..4286965 + 957 WP_053507632.1 GTPase -
DAX88_RS20560 (4287040) 4287040..4287342 - 303 WP_023247535.1 BrnA antitoxin family protein Antitoxin
DAX88_RS20565 (4287329) 4287329..4287616 - 288 WP_023247536.1 BrnT family toxin Toxin
DAX88_RS20570 (4287885) 4287885..4288799 - 915 WP_023247537.1 restriction endonuclease -
DAX88_RS20575 (4288997) 4288997..4292506 + 3510 WP_053529526.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11312.77 Da        Isoelectric Point: 8.5288

>T207634 WP_023247536.1 NZ_CP077710:c4287616-4287329 [Salmonella enterica subsp. enterica]
MPMEFEWDANKAKSNLNKHGIRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGYEVIRIIS
TRKADRKERNRYEHG

Download         Length: 288 bp

>T207634 NZ_CP103465:188059-188166 [Escherichia coli O25b:H4-ST131]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11397.04 Da        Isoelectric Point: 10.3140

>AT207634 WP_023247535.1 NZ_CP077710:c4287342-4287040 [Salmonella enterica subsp. enterica]
MSMVKHKRGNVPALSAQHEAELKALAKKSDDEIDYSDIPASENGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp

>AT207634 NZ_CP103465:c188010-187945 [Escherichia coli O25b:H4-ST131]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References