Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3779154..3779774 Replicon chromosome
Accession NZ_CP077710
Organism Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAX88_RS18135 Protein ID WP_001280991.1
Coordinates 3779556..3779774 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAX88_RS18130 Protein ID WP_000344807.1
Coordinates 3779154..3779528 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX88_RS18120 (3774291) 3774291..3775484 + 1194 WP_023246703.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAX88_RS18125 (3775507) 3775507..3778656 + 3150 WP_023246702.1 efflux RND transporter permease AcrB -
DAX88_RS18130 (3779154) 3779154..3779528 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAX88_RS18135 (3779556) 3779556..3779774 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAX88_RS18140 (3779954) 3779954..3780505 + 552 WP_053508533.1 maltose O-acetyltransferase -
DAX88_RS18145 (3780622) 3780622..3781092 + 471 WP_023246700.1 YlaC family protein -
DAX88_RS18150 (3781147) 3781147..3781287 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DAX88_RS18155 (3781293) 3781293..3781553 - 261 WP_023182818.1 type B 50S ribosomal protein L31 -
DAX88_RS18160 (3781778) 3781778..3783328 + 1551 WP_023246699.1 EAL domain-containing protein -
DAX88_RS18170 (3783559) 3783559..3783948 + 390 WP_023246698.1 MGMT family protein -
DAX88_RS18175 (3783981) 3783981..3784550 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207633 WP_001280991.1 NZ_CP077710:3779556-3779774 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207633 NZ_CP103456:c3611357-3611007 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
CTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207633 WP_000344807.1 NZ_CP077710:3779154-3779528 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207633 NZ_CP103456:c3611643-3611362 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCATATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References