Detailed information of TA system TA207632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3355244..3355891
• Replicon: chromosome
• Accession: NZ_CP077710
• Organism: Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A8E9YA31
• Locus tag: DAX88_RS16025
• Protein ID: WP_023246826.1
• Coordinates: 3355244..3355426 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A8F0CEZ4
• Locus tag: DAX88_RS16030
• Protein ID: WP_023246827.1
• Coordinates: 3355457..3355891 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX88_RS15995 (3350966)	3350966..3351319	-	354	WP_023248686.1	DUF1353 domain-containing protein	-
DAX88_RS16000 (3351320)	3351320..3352342	-	1023	WP_023248687.1	hypothetical protein	-
DAX88_RS16005 (3352352)	3352352..3352585	-	234	WP_023247427.1	hypothetical protein	-
DAX88_RS16010 (3352654)	3352654..3353175	-	522	WP_070790296.1	hypothetical protein	-
DAX88_RS25160 (3353175)	3353175..3353420	-	246	WP_230316504.1	tail fiber domain-containing protein	-
DAX88_RS25165 (3353523)	3353523..3353912	-	390	Protein_3169	collagen-like protein	-
DAX88_RS16020 (3354843)	3354843..3355157	-	315	Protein_3170	prophage tail fiber N-terminal domain-containing protein	-
DAX88_RS16025 (3355244)	3355244..3355426	+	183	WP_023246826.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAX88_RS16030 (3355457)	3355457..3355891	+	435	WP_023246827.1	hypothetical protein	Antitoxin
DAX88_RS16035 (3355914)	3355914..3356666	-	753	WP_070790279.1	hypothetical protein	-
DAX88_RS16040 (3356666)	3356666..3357022	-	357	WP_023246893.1	hypothetical protein	-
DAX88_RS16045 (3357032)	3357032..3360250	-	3219	WP_070795157.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	cdtB	3339225..3397215	57990

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (20-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6932.12 Da
• Isoelectric Point: 11.0888

>T207632 WP_023246826.1 NZ_CP077710:3355244-3355426 [Salmonella enterica subsp. enterica]
MKYNEFRRWLIRQGAKFINAPGGGSHQRVILNGRESVFPYHGAKEIPEPLRKKILKDLGL

Nucleotide

• Length: 183 bp

>T207632 NZ_CP103456:2759620-2760366 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTACCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCCTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCCTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15663.04 Da
• Isoelectric Point: 5.1799

>AT207632 WP_023246827.1 NZ_CP077710:3355457-3355891 [Salmonella enterica subsp. enterica]
MFNYAVKLEHDPDTKSWIATCRDLPLFNSVGDSVDDALLESVDGAIVALSIEIDARRPIPAASQPEEGEYVIHLPVLVVM
KAALHNAMIATGTRKSDLARSMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVNKVAA

Nucleotide

• Length: 435 bp

>AT207632 NZ_CP103456:2760366-2760536 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA