Detailed information of TA system TA020763

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 239751..240363
• Replicon: chromosome
• Accession: NC_004116
• Organism: Streptococcus agalactiae 2603V/R

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q8E1X3
• Locus tag: SAG_RS03850
• Protein ID: WP_000384858.1
• Coordinates: 239751..240086 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q8E1X2
• Locus tag: SAG_RS03855
• Protein ID: WP_000255538.1
• Coordinates: 240076..240363 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAG_RS03825 (SAG0223)	234949..235578	+	630	WP_000591149.1	hypothetical protein	-
SAG_RS03830 (SAG0224)	235891..236766	+	876	WP_000770113.1	hypothetical protein	-
SAG_RS03835 (SAG0225)	236802..237236	+	435	WP_001220479.1	hypothetical protein	-
SAG_RS03840 (SAG0226)	237552..238808	+	1257	WP_000122833.1	plasmid recombination protein	-
SAG_RS03845 (SAG0227)	238976..239446	+	471	WP_000130119.1	hypothetical protein	-
SAG_RS03850 (SAG0228)	239751..240086	-	336	WP_000384858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SAG_RS03855 (SAG0229)	240076..240363	-	288	WP_000255538.1	hypothetical protein	Antitoxin
SAG_RS03860 (SAG0230)	240870..241160	+	291	WP_000078283.1	WXG100 family type VII secretion target	-
SAG_RS03865 (SAG0231)	241262..241669	+	408	WP_000749954.1	hypothetical protein	-
SAG_RS03870 (SAG0232)	241669..242229	+	561	WP_001865562.1	hypothetical protein	-
SAG_RS03875 (SAG0233)	242202..242882	+	681	WP_001865565.1	hypothetical protein	-
SAG_RS03880 (SAG0234)	242867..243253	+	387	WP_000259069.1	hypothetical protein	-
SAG_RS03885 (SAG0235)	243287..243568	+	282	WP_000052406.1	hypothetical protein	-
SAG_RS03890 (SAG0239)	244411..245271	+	861	WP_000477654.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13264.04 Da
• Isoelectric Point: 5.2388

>T20763 WP_000384858.1 NC_004116:c240086-239751 [Streptococcus agalactiae 2603V/R]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISKYHSTRGYTLSKD
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Nucleotide

• Length: 336 bp

>T20763 NC_004116:c240086-239751 [Streptococcus agalactiae 2603V/R]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10921.47 Da
• Isoelectric Point: 4.7271

>AT20763 WP_000255538.1 NC_004116:c240363-240076 [Streptococcus agalactiae 2603V/R]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRSELGL

Nucleotide

• Length: 288 bp

>AT20763 NC_004116:c240363-240076 [Streptococcus agalactiae 2603V/R]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A0E1EF10

Antitoxin

• AlphaFold DB: A0A0E1EFF9