Detailed information of TA system TA207623

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 988395..989055
• Replicon: chromosome
• Accession: NZ_CP077710
• Organism: Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E9YGN6
• Locus tag: DAX88_RS04900
• Protein ID: WP_023249207.1
• Coordinates: 988642..989055 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: DAX88_RS04895
• Protein ID: WP_000351186.1
• Coordinates: 988395..988661 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX88_RS04875 (984336)	984336..985769	-	1434	WP_023249203.1	6-phospho-beta-glucosidase BglA	-
DAX88_RS04880 (985927)	985927..986238	+	312	WP_023249204.1	N(4)-acetylcytidine aminohydrolase	-
DAX88_RS04885 (986402)	986402..987061	+	660	WP_023249205.1	hemolysin III family protein	-
DAX88_RS04890 (987162)	987162..988142	-	981	WP_023249206.1	tRNA-modifying protein YgfZ	-
DAX88_RS04895 (988395)	988395..988661	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
DAX88_RS04900 (988642)	988642..989055	+	414	WP_023249207.1	protein YgfX	Toxin
DAX88_RS04905 (989107)	989107..989628	-	522	WP_023249208.1	flavodoxin FldB	-
DAX88_RS04910 (989741)	989741..990637	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
DAX88_RS04915 (990661)	990661..991374	+	714	WP_070788883.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DAX88_RS04920 (991380)	991380..993116	+	1737	WP_023249210.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16283.31 Da
• Isoelectric Point: 11.4501

>T207623 WP_023249207.1 NZ_CP077710:988642-989055 [Salmonella enterica subsp. enterica]
VVLWQSELRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLRSGMVLRLRAESGHHQHLWLAADSMEAAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T207623 NZ_CP103450:c858245-857934 [Erwinia pyrifoliae]
ATGCTTTTTATCGAAACCGCGATTTTCACAGAGGATGTAAAGGAACTGCTAACCGATGATGAATATCGAGAGTTTCAGCA
GTTCCTGGCTGATAACCCCGGCTGGGGCGACGTTATCCAGCAAACTGGCGGACTAAGAAAAGTCAGGTGGTCAGCCAAAG
GAAAAGGTAAACGTGGCGGGGTCAGGGTAATTTATTTTCACAAGGTGTCCGAGTCACAAATCAGATTGCTGCTCATCTAC
AAGAAAGGCATACAGGATGATCTCAGTGATGATGAAAAGCGGCAATTGAGAACACTCAACGAGGGGTGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT207623 WP_000351186.1 NZ_CP077710:988395-988661 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT207623 NZ_CP103450:c857931-857635 [Erwinia pyrifoliae]
ATGGAAAAAAAACTGTTTGAACGCCTGAAAGAAAGCATGACACAAATGAATGAAATCAATGAAGGTTCTCGCGATCCTTC
TCGCGAAACTAACGTCATTGCTGTTCAGGTTAAAGCGATACGAACGGCTTCCGGTCTGTCACAAAGTGGCTTCGCAAAAC
TGATCTCAGTAAATCTTGATACGCTCAAAAACTGGGAGCAAGGTCGGCGCGAACCCACCGGCCCGGCAAAAGCACTTTTA
AGGGCTATTGAGCGAGATCCGCAACATGTGATCCCTGCCCTTTCTGCCAAATCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4