Detailed information of TA system TA207622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 641124..641697
• Replicon: chromosome
• Accession: NZ_CP077710
• Organism: Salmonella enterica subsp. enterica strain CFSAN058540

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A8E9YDY4
• Locus tag: DAX88_RS03125
• Protein ID: WP_023246565.1
• Coordinates: 641124..641420 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DAX88_RS03130
• Protein ID: WP_023246564.1
• Coordinates: 641422..641697 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX88_RS03100 (636628)	636628..636924	+	297	WP_023246570.1	DUF4222 domain-containing protein	-
DAX88_RS03105 (636921)	636921..639071	+	2151	WP_023246569.1	DUF927 domain-containing protein	-
DAX88_RS03110 (639474)	639474..639929	+	456	WP_023246568.1	single-stranded DNA-binding protein	-
DAX88_RS03115 (639983)	639983..640582	+	600	WP_023246567.1	ProQ/FinO family protein	-
DAX88_RS03120 (640572)	640572..640784	+	213	WP_070788861.1	hypothetical protein	-
DAX88_RS03125 (641124)	641124..641420	+	297	WP_023246565.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DAX88_RS03130 (641422)	641422..641697	+	276	WP_023246564.1	putative addiction module antidote protein	Antitoxin
DAX88_RS03135 (641734)	641734..642072	+	339	WP_227005394.1	transcriptional regulator	-
DAX88_RS03140 (642155)	642155..642346	-	192	WP_024149539.1	hypothetical protein	-
DAX88_RS03145 (642590)	642590..642934	+	345	WP_023246561.1	single-stranded DNA-binding protein	-
DAX88_RS03150 (643416)	643416..643805	-	390	WP_070788863.1	hypothetical protein	-
DAX88_RS03155 (644787)	644787..644930	+	144	WP_023247172.1	hypothetical protein	-
DAX88_RS24875 (645053)	645053..645637	+	585	WP_070788864.1	FimD/PapC N-terminal domain-containing protein	-
DAX88_RS03165 (645819)	645819..646298	+	480	WP_070788865.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	631094..641697	10603

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (45-89)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11083.88 Da
• Isoelectric Point: 10.3907

>T207622 WP_023246565.1 NZ_CP077710:641124-641420 [Salmonella enterica subsp. enterica]
MIDIKTTPEAEKWLKGLKDRVAKSKILIRIDRMRTGNFGDVEPVGGGLSELRIHHGKGYRVYFGNKNNEIILILCGGDKS
TQQDDIQKAKQIAKKWGF

Nucleotide

• Length: 297 bp

>T207622 NZ_CP103450:c390513-390295 [Erwinia pyrifoliae]
ATGACTGACAAACTTCTTACGAAAACTGACTACCTGATGCGCCTCAGACGTTGTCGTTCAATCGACACCCTGGAACGCGT
GATTGAAAAGAACAAGTATGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCCGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTTGCCGTCTGGAAGTTTGTCCGTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10035.38 Da
• Isoelectric Point: 4.7683

>AT207622 WP_023246564.1 NZ_CP077710:641422-641697 [Salmonella enterica subsp. enterica]
MKQVLKDFDVADYLEDEDDVIAYLNAVIAEGDNKQLFIALGNIARARNISRISKETGISREGIYKALSGDGNPSFNTLSK
ITKAMGLDLHF

Nucleotide

• Length: 276 bp

>AT207622 NZ_CP103450:c390923-390543 [Erwinia pyrifoliae]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCACCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTACAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACAATGAATTACAAAATCAAGCATATCGAAGACTGCGATTTGATAAGTCAGATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTATGGCGTCAACACTCATGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCCTAATGAGCCAGGTTCAATCCAGCCATTCATTTTAG