Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 117705..118348 Replicon plasmid pCFSAN058545_01
Accession NZ_CP077707
Organism Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)


Gene name vagD Uniprot ID A0A632GNP3
Locus tag DAX52_RS23410 Protein ID WP_001644958.1
Coordinates 117705..118121 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag DAX52_RS23415 Protein ID WP_001644959.1
Coordinates 118118..118348 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX52_RS23390 (DAX52_023385) 113431..114405 - 975 WP_001644948.1 ParB family protein -
DAX52_RS23395 (DAX52_023390) 114405..115610 - 1206 WP_001644949.1 AAA family ATPase -
DAX52_RS23400 (DAX52_023395) 115858..116478 + 621 WP_001644950.1 recombinase family protein -
DAX52_RS23405 (DAX52_023400) 116614..117309 + 696 WP_024153690.1 IS6 family transposase -
DAX52_RS24475 117363..117563 + 201 Protein_124 Lrp/AsnC family transcriptional regulator -
DAX52_RS23410 (DAX52_023405) 117705..118121 - 417 WP_001644958.1 type II toxin-antitoxin system VapC family toxin Toxin
DAX52_RS23415 (DAX52_023410) 118118..118348 - 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DAX52_RS23420 (DAX52_023415) 118781..119044 + 264 WP_024153651.1 hypothetical protein -
DAX52_RS23425 (DAX52_023420) 119097..119486 - 390 Protein_128 IS3 family transposase -
DAX52_RS23430 (DAX52_023425) 119633..122443 - 2811 WP_070812003.1 autotransporter outer membrane beta-barrel domain-containing protein -
DAX52_RS23435 (DAX52_023430) 122764..123003 + 240 Protein_130 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroN 1..137180 137180


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15078.48 Da        Isoelectric Point: 9.1880

>T207620 WP_001644958.1 NZ_CP077707:c118121-117705 [Salmonella enterica subsp. enterica]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

>T207620 NZ_CP103450:32159-32572 [Erwinia pyrifoliae]
GTGGTCCTGTGGCAATGTGAACTGCGTCAGTCAAAGCTGGCACAGCGGCTTTCGCTGCTGCTGCATGGGGCAGTGATGCT
GGCGCTGCTACTGCCTGCATGGCCCGCCAGCGCTGGCCTGGTACGGATGCTGTTGCTGGTTTTGGTACTGCTGGAGTGCA
TACGCAGCCGGCGGCGCATCCGCCGCCGCCAGGGTGATGTCGCCCTGTTGGGCGGACATGCGCTACGCTGGCGGCAGCGC
GAGTGGCGCATCCTTTCCCGCCCGTGGCTTACCCGGCAGGCGATCCTGCTGTCACTGCGTGATGCCAAAGGGGAGCGTGA
ACGGCTGTGGCTGTTCGCCGACGGCATGGCAGACAGTCACTGGCGTCGGTTACGTATGCAGTTGCTGAACAATAAGGAGC
AGGGGAATGGATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT207620 WP_001644959.1 NZ_CP077707:c118348-118118 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp

>AT207620 NZ_CP103450:31912-32178 [Erwinia pyrifoliae]
ATGGATATTACAAATAAATCACGTATTCACTGGGCATGCCGTCGCGGCATGCGCGAACTGGATATCTCGATCATGCCGTT
TTTTCAGTACGAATTTGACTCGCTGAACGATGGCGATAAGCGTCTGTTTGTCCGCCTGTTAGAGAGCGACGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGAGAGCCGGCAGATGCGGAGCTGAAAAGGATGGTGTTGCTTATCCAGCAGAGAAAT
AAACAACGTGGTCCTGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A632GNP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References