Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3612400..3613072 Replicon chromosome
Accession NC_004088
Organism Yersinia pestis KIM10+

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag Y_RS16880 Protein ID WP_002215144.1
Coordinates 3612400..3612825 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag Y_RS16885 Protein ID WP_002209939.1
Coordinates 3612806..3613072 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y_RS16860 3608073..3608591 + 519 WP_002209934.1 flavodoxin FldB -
Y_RS16865 3608681..3610138 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
Y_RS16870 3610259..3611677 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
Y_RS16875 3611702..3612400 - 699 WP_002209937.1 two-component system response regulator CreB -
Y_RS16880 3612400..3612825 - 426 WP_002215144.1 protein YgfX Toxin
Y_RS16885 3612806..3613072 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
Y_RS16890 3613389..3614381 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
Y_RS16895 3614454..3614951 - 498 WP_002209941.1 DUF2165 family protein -
Y_RS16900 3615209..3615910 - 702 WP_002209942.1 hemolysin III family protein -
Y_RS16905 3616112..3617215 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T20762 WP_002215144.1 NC_004088:c3612825-3612400 [Yersinia pestis KIM10+]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T20762 NC_004088:c3612825-3612400 [Yersinia pestis KIM10+]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCACACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCGATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCACGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT20762 WP_002209939.1 NC_004088:c3613072-3612806 [Yersinia pestis KIM10+]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT20762 NC_004088:c3613072-3612806 [Yersinia pestis KIM10+]
ATGGAAATTGATAATAAAGCCCGTATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGACCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References