Detailed information of TA system TA207617

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4248409..4249190
• Replicon: chromosome
• Accession: NZ_CP077706
• Organism: Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A0R9NZI3
• Locus tag: DAX52_RS20635
• Protein ID: WP_000625912.1
• Coordinates: 4248409..4248900 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: M7RNV8
• Locus tag: DAX52_RS20640
• Protein ID: WP_001110450.1
• Coordinates: 4248897..4249190 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX52_RS20600 (4243820)	4243820..4244167	+	348	WP_000887832.1	divalent cation tolerance protein CutA	-
DAX52_RS20605 (4244143)	4244143..4245846	+	1704	WP_000068889.1	protein-disulfide reductase DsbD	-
DAX52_RS20610 (4245883)	4245883..4246458	+	576	WP_001188509.1	transcriptional regulator	-
DAX52_RS20620 (4246729)	4246729..4246803	-	75	Protein_4053	helix-turn-helix domain-containing protein	-
DAX52_RS20625 (4247183)	4247183..4247260	+	78	Protein_4054	porin family protein	-
DAX52_RS20630 (4247360)	4247360..4248112	+	753	WP_070794150.1	non-specific acid phosphatase	-
DAX52_RS20635 (4248409)	4248409..4248900	-	492	WP_000625912.1	GNAT family N-acetyltransferase	Toxin
DAX52_RS20640 (4248897)	4248897..4249190	-	294	WP_001110450.1	DUF1778 domain-containing protein	Antitoxin
DAX52_RS24420 (4249507)	4249507..4249716	+	210	Protein_4058	hypothetical protein	-
DAX52_RS20645 (4249980)	4249980..4250855	+	876	WP_000921676.1	AraC family transcriptional regulator	-
DAX52_RS20650 (4250852)	4250852..4251139	+	288	WP_001269916.1	transcriptional regulator RtsB	-
DAX52_RS24425 (4251132)	4251132..4251314	-	183	WP_001527266.1	ATP-binding cassette domain-containing protein	-
DAX52_RS24430 (4251334)	4251334..4251433	+	100	Protein_4062	hypothetical protein	-
DAX52_RS24435 (4251543)	4251543..4251677	+	135	Protein_4063	hypothetical protein	-
DAX52_RS20660 (4251972)	4251972..4252877	-	906	WP_001268209.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17606.43 Da
• Isoelectric Point: 7.7297

>T207617 WP_000625912.1 NZ_CP077706:c4248900-4248409 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T207617 NZ_CP103445:3542826-3543110 [Erwinia pyrifoliae]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10949.56 Da
• Isoelectric Point: 8.6141

>AT207617 WP_001110450.1 NZ_CP077706:c4249190-4248897 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT207617 NZ_CP103445:3542594-3542836 [Erwinia pyrifoliae]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0R9NZI3

Antitoxin

• AlphaFold DB: A0A0R9PGG6