Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4108045..4108561 Replicon chromosome
Accession NZ_CP077706
Organism Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAX52_RS19805 Protein ID WP_000220578.1
Coordinates 4108045..4108329 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DAX52_RS19810 Protein ID WP_000212724.1
Coordinates 4108319..4108561 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX52_RS19790 (4103161) 4103161..4104813 + 1653 WP_000155035.1 alpha,alpha-phosphotrehalase -
DAX52_RS19795 (4105222) 4105222..4107360 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
DAX52_RS19800 (4107577) 4107577..4108041 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX52_RS19805 (4108045) 4108045..4108329 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX52_RS19810 (4108319) 4108319..4108561 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX52_RS19815 (4108639) 4108639..4110552 - 1914 WP_001212131.1 BglG family transcription antiterminator -
DAX52_RS19820 (4110569) 4110569..4111309 - 741 WP_000779263.1 KDGP aldolase family protein -
DAX52_RS19825 (4111306) 4111306..4112424 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX52_RS19830 (4112408) 4112408..4113541 - 1134 WP_001636647.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207616 WP_000220578.1 NZ_CP077706:c4108329-4108045 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207616 NZ_CP103445:3528810-3529094 [Erwinia pyrifoliae]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207616 WP_000212724.1 NZ_CP077706:c4108561-4108319 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207616 NZ_CP103445:3528578-3528820 [Erwinia pyrifoliae]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References