Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3416370..3416990 Replicon chromosome
Accession NZ_CP077706
Organism Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAX52_RS16620 Protein ID WP_001280991.1
Coordinates 3416772..3416990 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAX52_RS16615 Protein ID WP_000344807.1
Coordinates 3416370..3416744 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX52_RS16605 (3411509) 3411509..3412702 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAX52_RS16610 (3412725) 3412725..3415874 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DAX52_RS16615 (3416370) 3416370..3416744 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAX52_RS16620 (3416772) 3416772..3416990 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAX52_RS16625 (3417169) 3417169..3417720 + 552 WP_001278786.1 maltose O-acetyltransferase -
DAX52_RS16630 (3417837) 3417837..3418307 + 471 WP_000136183.1 YlaC family protein -
DAX52_RS16635 (3418362) 3418362..3418502 - 141 WP_070794274.1 type B 50S ribosomal protein L36 -
DAX52_RS16640 (3418508) 3418508..3418768 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DAX52_RS16645 (3418993) 3418993..3420543 + 1551 WP_001642888.1 EAL domain-containing protein -
DAX52_RS16655 (3420774) 3420774..3421163 + 390 WP_000961285.1 MGMT family protein -
DAX52_RS16660 (3421196) 3421196..3421765 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207615 WP_001280991.1 NZ_CP077706:3416772-3416990 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207615 NZ_CP103445:3514059-3514343 [Erwinia pyrifoliae]
ATGAGCTATGAACTGGTCTTCGATCCCAGAGCCTTAAAAGAGTGGAAAAAACTGGGCGCAACGGTTCGGGAGCAGTTCAA
AAAGAAACTGGCGGAAGTGCTGGTAAACCCGAGGGTGGAATCTGCCAGGTTGAGAGAGTACCCGGACTGCTACAAAATAA
AGCTGAAATCATCGGGTTATCGTCTGGTATATCAGGTTCAGGATGAACAGCTGGTTGTCTTCGTTGTGGCGACAGGAAAA
AGAGAAAGGTTACAGGTGTATCGTGACGCAGGAAAGCGCCTGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207615 WP_000344807.1 NZ_CP077706:3416370-3416744 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207615 NZ_CP103445:3513827-3514069 [Erwinia pyrifoliae]
ATGGCAACATTAAACGTGCGGCTGGATGACAAGCTGAAAAGCAAAGCTTACGCAGTCCTGGATGAACTGGATGTATCACC
AACAGAGGCGGTCCGGCTGCTGTTCCAGTATATAGCGGAAAATGAACGTCTGCCGCTGAAAACGCTGACGGTCAGCGATG
AAGAGGACGCGCTGCTCAAAACGGTGCGCGAAAGGCTGGCATCGCCACAGAAGGGAATAAGGGTCACGCTGGATGAGCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References