Detailed information of TA system TA207614

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2115045..2115690
• Replicon: chromosome
• Accession: NZ_CP077706
• Organism: Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Z7XAV3
• Locus tag: DAX52_RS10200
• Protein ID: WP_070800844.1
• Coordinates: 2115508..2115690 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: DAX52_RS10195
• Protein ID: WP_108443194.1
• Coordinates: 2115045..2115479 (-)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX52_RS10180 (2110146)	2110146..2110889	+	744	WP_024154110.1	C40 family peptidase	-
DAX52_RS10185 (2110787)	2110787..2111494	+	708	WP_031604554.1	tail assembly protein	-
DAX52_RS10190 (2111565)	2111565..2114978	+	3414	WP_258229626.1	host specificity protein J	-
DAX52_RS10195 (2115045)	2115045..2115479	-	435	WP_108443194.1	hypothetical protein	Antitoxin
DAX52_RS10200 (2115508)	2115508..2115690	-	183	WP_070800844.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAX52_RS10205 (2115779)	2115779..2116660	+	882	WP_070794208.1	prophage tail fiber N-terminal domain-containing protein	-
DAX52_RS10210 (2116671)	2116671..2117264	+	594	WP_065314116.1	DUF4376 domain-containing protein	-
DAX52_RS10215 (2117372)	2117372..2117746	+	375	WP_058645172.1	DUF1353 domain-containing protein	-
DAX52_RS10220 (2118023)	2118023..2118286	-	264	WP_058645171.1	hypothetical protein	-
DAX52_RS10225 (2118286)	2118286..2120400	-	2115	WP_220571663.1	colicin-like bacteriocin tRNase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2072275..2128567	56292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-82)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6892.08 Da
• Isoelectric Point: 10.4804

>T207614 WP_070800844.1 NZ_CP077706:c2115690-2115508 [Salmonella enterica subsp. enterica]
MKYNEFRRWLIQQGAKFINAPDGGSHQRVILNGKESVFPCHGAKEMPEPLRKKILKDLGL

Nucleotide

• Length: 183 bp

>T207614 NZ_CP103445:c2846180-2845893 [Erwinia pyrifoliae]
TTGATTTATAAGGTTAAAATCAGGGCAGAAGCCCTGAAAGAATGGCATGGTTTGGACAGTGCCGTTCGGGAGCAATTTAG
TAAAAAACTTAAAAAATTGCGTGAAAATCCGCATGTACCTTCAGCCAGGCTAACGGGAATAGCGGGATGTTACAAAATAA
AACTCAGGTCTTCCGGCTTTCGGCTGGTATATCAGGTTATTGATGAAGAGCTGATTATAGCTGTGGTAGCTGTTGGAAAA
AGAGAGCGCAGCCAGGCATATAAACTTGCAAGCGAAAGGTTGCGGTGA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 15876.31 Da
• Isoelectric Point: 4.7323

>AT207614 WP_108443194.1 NZ_CP077706:c2115479-2115045 [Salmonella enterica subsp. enterica]
MFNYAVKPEYDPATESWVVTCRDLPLFNSVSFSIDDALLEAVDGAIVALSIEIDARRPVPIASQPEEGEYVIHLPVLVVM
KAALHNAMISTGTRKSDLARTMRMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVDNVAV

Nucleotide

• Length: 435 bp

>AT207614 NZ_CP103445:c2846427-2846185 [Erwinia pyrifoliae]
ATGGCAAATCTCATTCTTAGTGATACCAGTGCAAGCGTAAGCGAGCTTAAAAAGAATCCGATGGCTACAGTTGATGCCGG
TTGCGGCTTTCCTGTAGCGATTCTCAACCGCAATCAGCCCGCTTTCTACTGCATCCCTGCACCACTCTATGAGCGCATGC
TGGAAGTGATAGACGATCAGGAACTGGTCACGCTGGTTAAAGCGCGTGAAAATCAACCTCTGATAGATCTCGATCTGGAC
TAA

Structures

Toxin

• AlphaFold DB: A0A5Z7XAV3