Detailed information of TA system TA207613

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2088909..2089547
• Replicon: chromosome
• Accession: NZ_CP077706
• Organism: Salmonella enterica subsp. enterica strain CFSAN058545

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Z7XAU3
• Locus tag: DAX52_RS10050
• Protein ID: WP_072209095.1
• Coordinates: 2089365..2089547 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A5W1Z1L9
• Locus tag: DAX52_RS10045
• Protein ID: WP_058645062.1
• Coordinates: 2088909..2089322 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX52_RS10020 (2084275)	2084275..2084502	+	228	WP_058645057.1	hypothetical protein	-
DAX52_RS10025 (2084581)	2084581..2086530	+	1950	WP_070809061.1	replication endonuclease	-
DAX52_RS10030 (2086588)	2086588..2086956	+	369	WP_024154301.1	hypothetical protein	-
DAX52_RS10035 (2086979)	2086979..2088115	+	1137	WP_044144940.1	DUF968 domain-containing protein	-
DAX52_RS10040 (2088112)	2088112..2088765	+	654	WP_070804841.1	bacteriophage antitermination protein Q	-
DAX52_RS10045 (2088909)	2088909..2089322	-	414	WP_058645062.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
DAX52_RS10050 (2089365)	2089365..2089547	-	183	WP_072209095.1	type II toxin-antitoxin system HicA family toxin	Toxin
DAX52_RS10055 (2089933)	2089933..2090445	+	513	WP_000259586.1	DUF1440 domain-containing protein	-
DAX52_RS10060 (2091131)	2091131..2091487	+	357	WP_070809063.1	hypothetical protein	-
DAX52_RS10065 (2091515)	2091515..2091700	-	186	WP_070809064.1	hypothetical protein	-
DAX52_RS10070 (2092002)	2092002..2092220	+	219	WP_058645066.1	phage holin	-
DAX52_RS10075 (2092198)	2092198..2092737	+	540	WP_108443197.1	lysozyme	-
DAX52_RS10080 (2092838)	2092838..2093302	+	465	WP_070809066.1	lysis protein	-
DAX52_RS10085 (2093334)	2093334..2093624	-	291	WP_070809067.1	Bor family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2072275..2128567	56292

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6891.15 Da
• Isoelectric Point: 10.8877

>T207613 WP_072209095.1 NZ_CP077706:c2089547-2089365 [Salmonella enterica subsp. enterica]
MKSSELIKLLESKGWTLERINGSHHHFSHPDFPVIITVPHPRKDIKPGTLNQILKKAKLK

Nucleotide

• Length: 183 bp

>T207613 NZ_CP103445:2718048-2718266 [Erwinia pyrifoliae]
ATGACTGACAAACTTCTTACGAAAACTGACTACCTGATGCGCCTCAGACGTTGTCGTTCAATCGACACCCTGGAACGCGT
GATTGAAAAGAACAAGTATGAATTATCTGATGATGAACTGGCTGTATTTTATTCAGCCGCCGATCACCGTCTTGCCGAAC
TAACCATGAATAAGCTGTACGACAAAGTACCGGTTGCCGTCTGGAAGTTTGTCCGTTAA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15250.99 Da
• Isoelectric Point: 4.5174

>AT207613 WP_058645062.1 NZ_CP077706:c2089322-2088909 [Salmonella enterica subsp. enterica]
MLYPAFIEVDKDGSASGWFPDVPGCIFAGSTIEETYADARSAICAHFEVLCDKGFDIPSPRSIEQHVAAEPDDYSNGRWL
YVDVNMDQFDGRAERINVTLPHRLLDRIDATVKQHPDYGSRSAFLAAAARNELQKSL

Nucleotide

• Length: 414 bp

>AT207613 NZ_CP103445:2717638-2718018 [Erwinia pyrifoliae]
ATGGACGAATACTCACCGAAAAGGCATGATATTGCGCAGCTGAAATTCTTATGTGAAAACCTGTATGATGAAAGTCTGGC
TACGTTAGGCGACAGCCACCATGGCTGGGTTAACGACCCCACCTCAACGAGCAATCTACAGCTTAACGACCTGATAGAGC
ACATTGCAGCATTCACTATGAATTACAAAATCAAGCATATCGAAGACTGCGATTTGATAAGTCAGATTGATGAGTATCTG
GACGACACCTTTATGCTTTTCAGCAATTATGGCGTCAATACTCATGACTTACAACGCTGGCAAAAATCAGCGAAGCGATT
GTTTAACATTTTTGCTAAAGAATGCCTAATGAGCCAGGTTCAATCCAGCCATTCATTTTAG

Structures

Toxin

• AlphaFold DB: A0A5Z7XAU3

Antitoxin

• AlphaFold DB: A0A5W1Z1L9