Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 59955..60480 Replicon plasmid pCFSAN058565
Accession NZ_CP077705
Organism Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)


Gene name ccdB Uniprot ID I3VZQ7
Locus tag DBO17_RS23930 Protein ID WP_001159874.1
Coordinates 59955..60260 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag DBO17_RS23935 Protein ID WP_000813642.1
Coordinates 60262..60480 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBO17_RS23905 (DBO17_023905) 56596..56830 + 235 Protein_60 Rpn family recombination-promoting nuclease/putative transposase -
DBO17_RS23910 (DBO17_023910) 57137..57832 - 696 WP_000389613.1 type II CAAX endopeptidase family protein -
DBO17_RS23915 (DBO17_023915) 58336..59118 - 783 WP_000082174.1 site-specific integrase -
DBO17_RS24255 59131..59666 - 536 Protein_63 cytoplasmic protein -
DBO17_RS23925 (DBO17_023925) 59663..59953 - 291 WP_001266178.1 hypothetical protein -
DBO17_RS23930 (DBO17_023930) 59955..60260 - 306 WP_001159874.1 type II toxin-antitoxin system toxin CcdB Toxin
DBO17_RS23935 (DBO17_023935) 60262..60480 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
DBO17_RS23940 (DBO17_023940) 61190..61435 + 246 WP_000368362.1 hypothetical protein -
DBO17_RS23945 (DBO17_023945) 61440..62402 + 963 WP_000169858.1 hypothetical protein -
DBO17_RS24260 62480..62611 - 132 Protein_69 proQ/FINO family protein -
DBO17_RS23950 (DBO17_023950) 64070..64564 + 495 WP_000786171.1 hypothetical protein -
DBO17_RS23955 (DBO17_023955) 64624..65190 + 567 WP_258229783.1 Saf-pilin pilus formation protein SafA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..67728 67728


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11605.34 Da        Isoelectric Point: 5.6919

>T207602 WP_001159874.1 NZ_CP077705:c60260-59955 [Salmonella enterica subsp. enterica]
MQFKVYTYKRESRYTLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESWRLMTTDMASVPASVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

>T207602 NZ_CP103420:c5208931-5208014 [Klebsiella variicola]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCTAATCTGCAACAACAG
GCGGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGAAAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACACG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCGTTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8328.19 Da        Isoelectric Point: 4.5358

>AT207602 WP_000813642.1 NZ_CP077705:c60480-60262 [Salmonella enterica subsp. enterica]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRNW

Download         Length: 219 bp

>AT207602 NZ_CP103420:c5209695-5208937 [Klebsiella variicola]
ATGCCATCAAAATTAAACTGGCTGCTGCAAAACAGTGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCGGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACACGCAAAGTGGCTGGTTAAAAAAACGAGGCAACGGCGTATACGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTAGCCGCTCCGGTGTATGTCGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGTCGTTCACACTATCTACAGCTCAAACAAAACCAGTGCTGGTTGAGTATGGAAAATAAAGCGCT
GCTGCCAAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGCAAAAACTGCCGGTGCTGGATGATA
AATACCGCGTAACGCTTGATGTAAAAGGGAAAAGACTCACCGGCAGTGCGCCGGAACTGGCTGCTTACGAGTTGTTGAGC
GCGGTACCGGGGACCCTCTCATTTAACCACGCGGCAGAGCTTTTCCAGGGACTATTTAATCTTAATCCTCGTAAAGTAGA
GTATCTGCTTTCTGTCAGCCAGTCCGTGCAGACCAAGCGTTTGTATCTCTTTTTCGCCAGTTTTTACGAGCATGGTTGGC
TCAGACGAATCGATAGCCAAAAAATCGATCTGGGTGCGGGTAAGCGGCAAATCGTGGTAAATGGCAAGTTCAATGCTCAA
TATCAAATCACTGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A600Z065

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References