Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3512308..3512928 Replicon chromosome
Accession NZ_CP077704
Organism Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DBO17_RS17250 Protein ID WP_001280991.1
Coordinates 3512710..3512928 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DBO17_RS17245 Protein ID WP_000344807.1
Coordinates 3512308..3512682 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBO17_RS17235 (3507447) 3507447..3508640 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DBO17_RS17240 (3508663) 3508663..3511812 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DBO17_RS17245 (3512308) 3512308..3512682 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DBO17_RS17250 (3512710) 3512710..3512928 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DBO17_RS17255 (3513107) 3513107..3513658 + 552 WP_001278792.1 maltose O-acetyltransferase -
DBO17_RS17260 (3513775) 3513775..3514245 + 471 WP_000136181.1 YlaC family protein -
DBO17_RS17265 (3514301) 3514301..3514441 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DBO17_RS17270 (3514447) 3514447..3514707 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DBO17_RS17275 (3514932) 3514932..3516482 + 1551 WP_079960057.1 EAL domain-containing protein -
DBO17_RS17285 (3516713) 3516713..3517102 + 390 WP_000961285.1 MGMT family protein -
DBO17_RS17290 (3517135) 3517135..3517704 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207595 WP_001280991.1 NZ_CP077704:3512710-3512928 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207595 NZ_CP103420:321092-321460 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGACGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGTGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207595 WP_000344807.1 NZ_CP077704:3512308-3512682 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207595 NZ_CP103420:320874-321095 [Klebsiella variicola]
ATGAGAACGGTTAACTATAGCGAAGCCCGACAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTATACCTGTCAC
CATTACCCGTCGTGGGCATAAATCTGCGGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATTATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References