207594

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2403199..2403721 Replicon chromosome
Accession NZ_CP077704
Organism Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag DBO17_RS11640 Protein ID WP_000221345.1
Coordinates 2403437..2403721 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag DBO17_RS11635 Protein ID WP_000885424.1
Coordinates 2403199..2403447 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBO17_RS11620 (2399171) 2399171..2400373 + 1203 WP_258229774.1 hypothetical protein -
DBO17_RS11625 (2400662) 2400662..2400943 + 282 WP_001580000.1 hypothetical protein -
DBO17_RS11630 (2401231) 2401231..2401563 - 333 WP_001580001.1 DUF1493 family protein -
DBO17_RS24090 (2402214) 2402214..2402330 - 117 Protein_2291 IS110 family transposase -
DBO17_RS24095 (2402433) 2402433..2402786 + 354 WP_079960300.1 hypothetical protein -
DBO17_RS11635 (2403199) 2403199..2403447 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DBO17_RS11640 (2403437) 2403437..2403721 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DBO17_RS11645 (2403892) 2403892..2404281 + 390 WP_079960311.1 RidA family protein -
DBO17_RS11650 (2404339) 2404339..2405412 - 1074 WP_108408482.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
DBO17_RS11655 (2405605) 2405605..2406093 - 489 WP_023194239.1 MarR family winged helix-turn-helix transcriptional regulator -
DBO17_RS11660 (2406138) 2406138..2407646 + 1509 WP_079960302.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2398910..2410503 11593


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T207594 WP_000221345.1 NZ_CP077704:2403437-2403721 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T207594 NZ_CP103419:c5433666-5433283 [Klebsiella variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT207594 WP_000885424.1 NZ_CP077704:2403199-2403447 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT207594 NZ_CP103419:c5433908-5433666 [Klebsiella variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References