Detailed information of TA system TA207583

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 827264..827924
• Replicon: chromosome
• Accession: NZ_CP077704
• Organism: Salmonella enterica subsp. enterica strain CFSAN058565

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: DBO17_RS03990
• Protein ID: WP_079959849.1
• Coordinates: 827511..827924 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: DBO17_RS03985
• Protein ID: WP_000351186.1
• Coordinates: 827264..827530 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DBO17_RS03965 (823193)	823193..824626	-	1434	WP_001230140.1	6-phospho-beta-glucosidase BglA	-
DBO17_RS03970 (824784)	824784..825095	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
DBO17_RS03975 (825259)	825259..825918	+	660	WP_000250289.1	hemolysin III family protein	-
DBO17_RS03980 (826034)	826034..827014	-	981	WP_000874178.1	tRNA-modifying protein YgfZ	-
DBO17_RS03985 (827264)	827264..827530	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
DBO17_RS03990 (827511)	827511..827924	+	414	WP_079959849.1	protein YgfX	Toxin
DBO17_RS03995 (827977)	827977..828498	-	522	WP_001055885.1	flavodoxin FldB	-
DBO17_RS04000 (828611)	828611..829507	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
DBO17_RS04005 (829531)	829531..830244	+	714	WP_000745614.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
DBO17_RS04010 (830250)	830250..831983	+	1734	WP_000813387.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16208.16 Da
• Isoelectric Point: 10.7538

>T207583 WP_079959849.1 NZ_CP077704:827511-827924 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGH
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Nucleotide

• Length: 414 bp

>T207583 NZ_CP103417:c1280131-1279886 [Brucella melitensis]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTTCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT207583 WP_000351186.1 NZ_CP077704:827264-827530 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT207583 NZ_CP103417:c1279886-1279572 [Brucella melitensis]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAGGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATAAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAATCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4