Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4168467..4169248 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A752VN12
Locus tag DAX60_RS20245 Protein ID WP_000622305.1
Coordinates 4168467..4168958 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A3V4SIN7
Locus tag DAX60_RS20250 Protein ID WP_001110453.1
Coordinates 4168955..4169248 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS20215 (4163830) 4163830..4164678 - 849 WP_000175389.1 SdiA-regulated domain-containing protein -
DAX60_RS20220 (4164704) 4164704..4164865 - 162 WP_001816720.1 hypothetical protein -
DAX60_RS20225 (4164904) 4164904..4165443 - 540 Protein_3985 fimbria/pilus periplasmic chaperone -
DAX60_RS20230 (4165466) 4165466..4166719 - 1254 WP_259406988.1 fimbria/pilus outer membrane usher protein -
DAX60_RS23240 (4166705) 4166705..4166908 - 204 Protein_3987 transcriptional regulator -
DAX60_RS20235 (4167501) 4167501..4167728 + 228 WP_001112992.1 hypothetical protein -
DAX60_RS20240 (4168003) 4168003..4168251 - 249 Protein_3989 IS481 family transposase -
DAX60_RS20245 (4168467) 4168467..4168958 - 492 WP_000622305.1 GNAT family N-acetyltransferase Toxin
DAX60_RS20250 (4168955) 4168955..4169248 - 294 WP_001110453.1 DUF1778 domain-containing protein Antitoxin
DAX60_RS23245 (4169566) 4169566..4169788 + 223 Protein_3992 hypothetical protein -
DAX60_RS20255 (4170052) 4170052..4170927 + 876 WP_000921676.1 AraC family transcriptional regulator -
DAX60_RS20260 (4170924) 4170924..4171211 + 288 WP_001269916.1 transcriptional regulator RtsB -
DAX60_RS23250 (4171204) 4171204..4171386 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
DAX60_RS23255 (4171406) 4171406..4171505 + 100 Protein_3996 hypothetical protein -
DAX60_RS23260 (4171615) 4171615..4171749 + 135 Protein_3997 hypothetical protein -
DAX60_RS20270 (4172044) 4172044..4172949 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(2-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T207578 WP_000622305.1 NZ_CP077702:c4168958-4168467 [Salmonella enterica subsp. enterica]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T207578 NZ_CP103412:c1297591-1296845 [Bacillus velezensis]
ATGCTTATGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10948.57 Da        Isoelectric Point: 9.8590

>AT207578 WP_001110453.1 NZ_CP077702:c4169248-4168955 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT207578 NZ_CP103412:c1296844-1296674 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A752VN12

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIN7

References