Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4060696..4061212 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAX60_RS19660 Protein ID WP_000220578.1
Coordinates 4060696..4060980 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A616DWW4
Locus tag DAX60_RS19665 Protein ID WP_001527600.1
Coordinates 4060970..4061212 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS19645 (4055812) 4055812..4057464 + 1653 WP_001527219.1 alpha,alpha-phosphotrehalase -
DAX60_RS19650 (4057873) 4057873..4060011 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DAX60_RS19655 (4060228) 4060228..4060692 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX60_RS19660 (4060696) 4060696..4060980 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX60_RS19665 (4060970) 4060970..4061212 - 243 WP_001527600.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX60_RS19670 (4061290) 4061290..4063203 - 1914 WP_058800113.1 BglG family transcription antiterminator -
DAX60_RS19675 (4063220) 4063220..4063960 - 741 WP_000779254.1 KDGP aldolase family protein -
DAX60_RS19680 (4063957) 4063957..4065075 - 1119 WP_001139190.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX60_RS19685 (4065059) 4065059..4066192 - 1134 WP_000459926.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-65)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207577 WP_000220578.1 NZ_CP077702:c4060980-4060696 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207577 NZ_CP103412:485703-486053 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCCT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8960.40 Da        Isoelectric Point: 8.5178

>AT207577 WP_001527600.1 NZ_CP077702:c4061212-4060970 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLKKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207577 NZ_CP103412:485416-485697 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A616DWW4

References