Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3995248..3995951 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name ypjF Uniprot ID A0A3V9YEG3
Locus tag DAX60_RS19355 Protein ID WP_000854678.1
Coordinates 3995248..3995589 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A3V3HFF7
Locus tag DAX60_RS19360 Protein ID WP_000842921.1
Coordinates 3995610..3995951 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS19340 (3991517) 3991517..3992233 + 717 WP_000532939.1 YebC/PmpR family DNA-binding transcriptional regulator -
DAX60_RS19345 (3992711) 3992711..3993586 - 876 WP_000199876.1 HNH endonuclease -
DAX60_RS19350 (3993982) 3993982..3994971 - 990 WP_077905735.1 restriction endonuclease -
DAX60_RS19355 (3995248) 3995248..3995589 - 342 WP_000854678.1 TA system toxin CbtA family protein Toxin
DAX60_RS19360 (3995610) 3995610..3995951 - 342 WP_000842921.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DAX60_RS19365 (3996319) 3996319..3998772 + 2454 WP_000985297.1 type I restriction-modification system subunit M -
DAX60_RS19370 (3998787) 3998787..4000148 + 1362 WP_001043545.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3993982..4021255 27273


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12780.67 Da        Isoelectric Point: 6.4593

>T207576 WP_000854678.1 NZ_CP077702:c3995589-3995248 [Salmonella enterica subsp. enterica]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNYLVEKYELVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAQ

Download         Length: 342 bp

>T207576 NZ_CP103403:66584-66871 [Pantoea agglomerans]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGATAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAACGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12882.63 Da        Isoelectric Point: 6.6253

>AT207576 WP_000842921.1 NZ_CP077702:c3995951-3995610 [Salmonella enterica subsp. enterica]
MKSTDSENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFINAEYLKLDEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 342 bp

>AT207576 NZ_CP103403:66336-66587 [Pantoea agglomerans]
ATGCCAAACATTATTTTAAGCGATACCAGTGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAGTGCAGG
TGACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTTTATGAACAAATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAACGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9YEG3

Antitoxin

Source ID Structure
AlphaFold DB A0A3V3HFF7

References