Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
Location | 3995248..3995951 | Replicon | chromosome |
Accession | NZ_CP077702 | ||
Organism | Salmonella enterica subsp. enterica strain CFSAN058588 |
Toxin (Protein)
Gene name | ypjF | Uniprot ID | A0A3V9YEG3 |
Locus tag | DAX60_RS19355 | Protein ID | WP_000854678.1 |
Coordinates | 3995248..3995589 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | yfjZ | Uniprot ID | A0A3V3HFF7 |
Locus tag | DAX60_RS19360 | Protein ID | WP_000842921.1 |
Coordinates | 3995610..3995951 (-) | Length | 114 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DAX60_RS19340 (3991517) | 3991517..3992233 | + | 717 | WP_000532939.1 | YebC/PmpR family DNA-binding transcriptional regulator | - |
DAX60_RS19345 (3992711) | 3992711..3993586 | - | 876 | WP_000199876.1 | HNH endonuclease | - |
DAX60_RS19350 (3993982) | 3993982..3994971 | - | 990 | WP_077905735.1 | restriction endonuclease | - |
DAX60_RS19355 (3995248) | 3995248..3995589 | - | 342 | WP_000854678.1 | TA system toxin CbtA family protein | Toxin |
DAX60_RS19360 (3995610) | 3995610..3995951 | - | 342 | WP_000842921.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
DAX60_RS19365 (3996319) | 3996319..3998772 | + | 2454 | WP_000985297.1 | type I restriction-modification system subunit M | - |
DAX60_RS19370 (3998787) | 3998787..4000148 | + | 1362 | WP_001043545.1 | restriction endonuclease subunit S | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3993982..4021255 | 27273 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12780.67 Da Isoelectric Point: 6.4593
>T207576 WP_000854678.1 NZ_CP077702:c3995589-3995248 [Salmonella enterica subsp. enterica]
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNYLVEKYELVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAQ
MKTLPATTPQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNYLVEKYELVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAQ
Download Length: 342 bp
>T207576 NZ_CP103403:66584-66871 [Pantoea agglomerans]
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGATAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAACGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG
GTGAGTTATACCGTCAAATTCAGGGAAGAGGCTTTTAAAGAGTGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGATAATCCCCATATTCCTTCTGCCAGACTACGTGGGATTAAAGACTGCTATAAAATCA
AACTCAGAACGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGACCAGCTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATGTTTATCATCTTGCCAGTGAAAGGATGCGGTAG
Antitoxin
Download Length: 114 a.a. Molecular weight: 12882.63 Da Isoelectric Point: 6.6253
>AT207576 WP_000842921.1 NZ_CP077702:c3995951-3995610 [Salmonella enterica subsp. enterica]
MKSTDSENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFINAEYLKLDEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR
MKSTDSENDLFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFINAEYLKLDEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTQR
Download Length: 342 bp
>AT207576 NZ_CP103403:66336-66587 [Pantoea agglomerans]
ATGCCAAACATTATTTTAAGCGATACCAGTGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAGTGCAGG
TGACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTTTATGAACAAATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAACGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA
ATGCCAAACATTATTTTAAGCGATACCAGTGCCAGCGTAAGCGAACTGAAGAAAAACCCGATGGCCACGGTTAGTGCAGG
TGACGGTTATCCTGTCGCCATTCTTAACCGCAACCAGCCTGCATTCTATTGCGTCCCGGCTGAGCTTTATGAACAAATGC
TTGATGCCCTTGACGATCAGGAACTGGTTAAGCTGGTCAGTGAACGCAGCGGCCAGCGTCTGCTTGATGTCGATTTGGAT
GCGCTTTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V9YEG3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3V3HFF7 |