Detailed information of TA system TA207575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3424582..3425202
• Replicon: chromosome
• Accession: NZ_CP077702
• Organism: Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: DAX60_RS16715
• Protein ID: WP_001280991.1
• Coordinates: 3424984..3425202 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: DAX60_RS16710
• Protein ID: WP_000344807.1
• Coordinates: 3424582..3424956 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX60_RS16700 (3419721)	3419721..3420914	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
DAX60_RS16705 (3420937)	3420937..3424086	+	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
DAX60_RS16710 (3424582)	3424582..3424956	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
DAX60_RS16715 (3424984)	3424984..3425202	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
DAX60_RS16720 (3425381)	3425381..3425932	+	552	WP_001278793.1	maltose O-acetyltransferase	-
DAX60_RS16725 (3426050)	3426050..3426520	+	471	WP_000136183.1	YlaC family protein	-
DAX60_RS16730 (3426576)	3426576..3426716	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
DAX60_RS16735 (3426722)	3426722..3426982	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
DAX60_RS16740 (3427207)	3427207..3428757	+	1551	WP_001529059.1	EAL domain-containing protein	-
DAX60_RS16750 (3428988)	3428988..3429377	+	390	WP_000961285.1	MGMT family protein	-
DAX60_RS16755 (3429410)	3429410..3429979	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T207575 WP_001280991.1 NZ_CP077702:3424984-3425202 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T207575 NZ_CP103403:c31285-30998 [Pantoea agglomerans]
ATGGCCTGGCAACTGGAGTTCGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCGGGATACCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGTATACCAGGTTATTGATGACCGGGTGGTGGTTTTTGTGGTGGCTGTCGGGAAA
AGAGAGCGCTCAGAGGTTTATTCTGCCGCTTCCAGGCGTCTCTCTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT207575 WP_000344807.1 NZ_CP077702:3424582-3424956 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT207575 NZ_CP103403:c31524-31285 [Pantoea agglomerans]
ATGGGCACAATTAACATTCGAATCGATGATGACCTGAAGACACGATCCTATGCTGCGCTCGAAAAAATGGGTGTGACTCC
TTCTGATGCGCTGCGCCTGATGCTTGAATATATTGCAGATAATGAACGTCTTCCCTTTAAGCAAACGTTACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTTAAAGAACGCCTGCAAAACCCTGAGCCTGTCCGGGTCACACTGGATGACCTTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0