Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3424582..3425202 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAX60_RS16715 Protein ID WP_001280991.1
Coordinates 3424984..3425202 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAX60_RS16710 Protein ID WP_000344807.1
Coordinates 3424582..3424956 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS16700 (3419721) 3419721..3420914 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAX60_RS16705 (3420937) 3420937..3424086 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DAX60_RS16710 (3424582) 3424582..3424956 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAX60_RS16715 (3424984) 3424984..3425202 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAX60_RS16720 (3425381) 3425381..3425932 + 552 WP_001278793.1 maltose O-acetyltransferase -
DAX60_RS16725 (3426050) 3426050..3426520 + 471 WP_000136183.1 YlaC family protein -
DAX60_RS16730 (3426576) 3426576..3426716 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DAX60_RS16735 (3426722) 3426722..3426982 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DAX60_RS16740 (3427207) 3427207..3428757 + 1551 WP_001529059.1 EAL domain-containing protein -
DAX60_RS16750 (3428988) 3428988..3429377 + 390 WP_000961285.1 MGMT family protein -
DAX60_RS16755 (3429410) 3429410..3429979 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207575 WP_001280991.1 NZ_CP077702:3424984-3425202 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207575 NZ_CP103403:c31285-30998 [Pantoea agglomerans]
ATGGCCTGGCAACTGGAGTTCGATCAGAGGGCACTGAAAGAGTGGCGCAAGCTGGGCCCGACAGTACGTGAACAGCTTAA
AAAGAAGCTGGCTGAGTGTCTTGAGTCACCCAGAATTGAGGCGAACAAACTCAGCGGGATACCTGACTGCTATAAGATCA
AGCTAAAGTCATCCGGTTATCGACTTGTATACCAGGTTATTGATGACCGGGTGGTGGTTTTTGTGGTGGCTGTCGGGAAA
AGAGAGCGCTCAGAGGTTTATTCTGCCGCTTCCAGGCGTCTCTCTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207575 WP_000344807.1 NZ_CP077702:3424582-3424956 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207575 NZ_CP103403:c31524-31285 [Pantoea agglomerans]
ATGGGCACAATTAACATTCGAATCGATGATGACCTGAAGACACGATCCTATGCTGCGCTCGAAAAAATGGGTGTGACTCC
TTCTGATGCGCTGCGCCTGATGCTTGAATATATTGCAGATAATGAACGTCTTCCCTTTAAGCAAACGTTACTCAGTGACG
AAGATGCGGCGTTAGTAGACATAGTTAAAGAACGCCTGCAAAACCCTGAGCCTGTCCGGGTCACACTGGATGACCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References