Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | stbDE/ParE-YafN |
| Location | 2393831..2394353 | Replicon | chromosome |
| Accession | NZ_CP077702 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058588 | ||
Toxin (Protein)
| Gene name | stbE | Uniprot ID | A0A5J1ICX1 |
| Locus tag | DAX60_RS11505 | Protein ID | WP_000221344.1 |
| Coordinates | 2394069..2394353 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | stbD | Uniprot ID | V1H457 |
| Locus tag | DAX60_RS11500 | Protein ID | WP_000885424.1 |
| Coordinates | 2393831..2394079 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX60_RS11470 (2389554) | 2389554..2389760 | - | 207 | WP_058661535.1 | helix-turn-helix transcriptional regulator | - |
| DAX60_RS11480 (2390899) | 2390899..2391207 | + | 309 | WP_143201336.1 | hypothetical protein | - |
| DAX60_RS11485 (2391204) | 2391204..2392613 | + | 1410 | WP_058661530.1 | DEAD/DEAH box helicase family protein | - |
| DAX60_RS11490 (2393142) | 2393142..2393474 | - | 333 | WP_000253078.1 | DUF1493 family protein | - |
| DAX60_RS11495 (2393560) | 2393560..2393679 | - | 120 | Protein_2262 | type II and III secretion system | - |
| DAX60_RS11500 (2393831) | 2393831..2394079 | + | 249 | WP_000885424.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| DAX60_RS11505 (2394069) | 2394069..2394353 | + | 285 | WP_000221344.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| DAX60_RS11510 (2394525) | 2394525..2394914 | + | 390 | WP_000194089.1 | RidA family protein | - |
| DAX60_RS11515 (2394972) | 2394972..2396045 | - | 1074 | WP_023226336.1 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase | - |
| DAX60_RS11520 (2396238) | 2396238..2396726 | - | 489 | WP_001293635.1 | MarR family winged helix-turn-helix transcriptional regulator | - |
| DAX60_RS11525 (2396771) | 2396771..2398279 | + | 1509 | WP_001527656.1 | FAD-dependent oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2389862..2401136 | 11274 | |
| - | flank | IS/Tn | - | - | 2390017..2390520 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11015.73 Da Isoelectric Point: 10.5388
>T207574 WP_000221344.1 NZ_CP077702:2394069-2394353 [Salmonella enterica subsp. enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS
Download Length: 285 bp
>T207574 NZ_CP103402:496741-497211 [Pantoea agglomerans]
TTGATTCTCTACAGGCTGACCAAGACAAAGTATCTTTCAACAGCCTGGACGGGATTTGGCGCAAAAGAGGCGGGCGGCCG
CTGGAACAGCATCGGCATCTCCATGGTTTATGTTTCTGAAACAGCATCACTGACTTTGCTGGAAACACTGGTCCATCTGC
ACTCAGCACACATCCTGGACGCATTCACACTTCTGCGCATCGATGTTCCCGATGCGTTGATTCAGACCGCTGATATCACT
GAGTTGCCTGCAAACTGGGCCGATGAAGACGCACCGGCAGAACTGGCTGACTATGGAGACGCCTGGTGCTCTGCCTGCGA
TGCGGTTGCGTTGCGTGTTCCCAGTGCCCTCTCCCCTGTAGAATATAACTACCTGTTAAATCCTGAACATCCCGAGTTCT
TCCGGATAGTTCAACAGGCTGAGGCCATTCCGTTCCGGTTTGATCGTCGGCTGAAACCGGATCGTAAATAA
TTGATTCTCTACAGGCTGACCAAGACAAAGTATCTTTCAACAGCCTGGACGGGATTTGGCGCAAAAGAGGCGGGCGGCCG
CTGGAACAGCATCGGCATCTCCATGGTTTATGTTTCTGAAACAGCATCACTGACTTTGCTGGAAACACTGGTCCATCTGC
ACTCAGCACACATCCTGGACGCATTCACACTTCTGCGCATCGATGTTCCCGATGCGTTGATTCAGACCGCTGATATCACT
GAGTTGCCTGCAAACTGGGCCGATGAAGACGCACCGGCAGAACTGGCTGACTATGGAGACGCCTGGTGCTCTGCCTGCGA
TGCGGTTGCGTTGCGTGTTCCCAGTGCCCTCTCCCCTGTAGAATATAACTACCTGTTAAATCCTGAACATCCCGAGTTCT
TCCGGATAGTTCAACAGGCTGAGGCCATTCCGTTCCGGTTTGATCGTCGGCTGAAACCGGATCGTAAATAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9090.32 Da Isoelectric Point: 3.9820
>AT207574 WP_000885424.1 NZ_CP077702:2393831-2394079 [Salmonella enterica subsp. enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL
Download Length: 249 bp
>AT207574 NZ_CP103402:496301-496744 [Pantoea agglomerans]
ATGAAAACATTCAGCTTTTCTGCGAACAAAACCAGGCCGCCACGCTTATGGCAGGCCGCAGGCCTGAACAACGCTGATGG
TGTCGCCCTGCTGGGCCAGATTAATGAAGGCCTTGATGGCAACGTAGCTCACCTGATCGTCAACTGGGCGAAGATTACGC
AAAACGACCTGCGCAAAATGTCCGGTATTCCCTCCACGACGTTCAGCCGAAGCGTGAAAGCGAAATTCAGCGCTGAACAA
AGTGAACGACTGGTACGTATTATCCGTGTCATTGATCGCGCAGTTGAACTGTTCGAAGGTGATAAGGATGAAGCGCAAAA
ATGGTTGAATGAGCCTAACAGGGCGCTGAGCTGGAAAATGCCCGCAGAACTGATGGCGTCTGAAACCGGGGCTTACGAGG
TCATGAAATTAATCACGCGCCTGGAGCACGGAGTTTACTCTTGA
ATGAAAACATTCAGCTTTTCTGCGAACAAAACCAGGCCGCCACGCTTATGGCAGGCCGCAGGCCTGAACAACGCTGATGG
TGTCGCCCTGCTGGGCCAGATTAATGAAGGCCTTGATGGCAACGTAGCTCACCTGATCGTCAACTGGGCGAAGATTACGC
AAAACGACCTGCGCAAAATGTCCGGTATTCCCTCCACGACGTTCAGCCGAAGCGTGAAAGCGAAATTCAGCGCTGAACAA
AGTGAACGACTGGTACGTATTATCCGTGTCATTGATCGCGCAGTTGAACTGTTCGAAGGTGATAAGGATGAAGCGCAAAA
ATGGTTGAATGAGCCTAACAGGGCGCTGAGCTGGAAAATGCCCGCAGAACTGATGGCGTCTGAAACCGGGGCTTACGAGG
TCATGAAATTAATCACGCGCCTGGAGCACGGAGTTTACTCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5J1ICX1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5I0WPN5 |