Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 818677..819337 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name cptA Uniprot ID A0A639BLH7
Locus tag DAX60_RS03940 Protein ID WP_001527988.1
Coordinates 818924..819337 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAX60_RS03935 Protein ID WP_000351186.1
Coordinates 818677..818943 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS03915 (814597) 814597..816030 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
DAX60_RS03920 (816188) 816188..816499 + 312 WP_001182972.1 N(4)-acetylcytidine aminohydrolase -
DAX60_RS03925 (816663) 816663..817322 + 660 WP_001528099.1 hemolysin III family protein -
DAX60_RS03930 (817447) 817447..818427 - 981 WP_001528035.1 tRNA-modifying protein YgfZ -
DAX60_RS03935 (818677) 818677..818943 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAX60_RS03940 (818924) 818924..819337 + 414 WP_001527988.1 protein YgfX Toxin
DAX60_RS03945 (819390) 819390..819911 - 522 WP_001055885.1 flavodoxin FldB -
DAX60_RS03950 (820024) 820024..820920 + 897 WP_000434300.1 site-specific tyrosine recombinase XerD -
DAX60_RS03955 (820944) 820944..821657 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAX60_RS03960 (821663) 821663..823396 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16148.13 Da        Isoelectric Point: 9.4814

>T207565 WP_001527988.1 NZ_CP077702:818924-819337 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGCHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207565 NZ_CP103399:c2184462-2184115 [Listeria innocua]
CTGATGGTGAAGCGTGGTGACGTTTACTACGCGGACCTTTCCCCCGTGGTCGGAAGCGAGCAAGGGGGAATAAGGCCTGT
TCTCATCATTCAAAATGATATTGGTAATAGATTCAGTCCAACTGTGATCGTGGCAGCAATAACTGCAAAAATTCAAAAAG
CGAAGTTGCCAACACATGTGGAAGCTACTCGTAAAGACGGCTTTGAAAGAGATTCTGTCATTCTATTAGAACAAATTAGA
ACGATAGATAAACAACGCCTGACAGATAAGATTACACATTTGGACGAGGAACTAATGGCCAAGGTAAATCAGGCACTTGA
AGTCAGTCTAGGAGTAGTAGAATTCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207565 WP_000351186.1 NZ_CP077702:818677-818943 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207565 NZ_CP103399:c2184744-2184466 [Listeria innocua]
GTGTTAGAGAAAGAAAAACGGATGATAATATCCGTAGAACTGACACAGGAAATGGTACAAGAACTCGACGTAGTTGTAGA
AAAAGAAAAAATGGGGCGGAGTGAAGTTATAATGGAAGCAACGCAACAATTTTTACAGGAGAAAAGAGCTCGTGAATTAA
GAGACGAGATGGAACGCGGCTATGCAGAAATGGCGACGATTAATTTCGCTATCGCGTGCGAGTGTACTCATGTCGAAGCA
GAGGCAGAAGACAGGAATATTAGTATTTTAGGAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A639BLH7

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References