Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 206042..206802 Replicon chromosome
Accession NZ_CP077702
Organism Salmonella enterica subsp. enterica strain CFSAN058588

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag DAX60_RS00965 Protein ID WP_000533909.1
Coordinates 206317..206802 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag DAX60_RS00960 Protein ID WP_000965886.1
Coordinates 206042..206329 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX60_RS23000 (202031) 202031..202495 + 465 Protein_187 IS3 family transposase -
DAX60_RS23005 (202619) 202619..203407 + 789 Protein_188 IS3 family transposase -
DAX60_RS00950 (203720) 203720..204712 + 993 WP_001528230.1 HNH endonuclease -
DAX60_RS00955 (204783) 204783..205409 - 627 WP_130559547.1 hypothetical protein -
DAX60_RS00960 (206042) 206042..206329 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
DAX60_RS00965 (206317) 206317..206802 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
DAX60_RS00970 (207173) 207173..207712 - 540 WP_000047140.1 copper-binding periplasmic metallochaperone CueP -
DAX60_RS00975 (207885) 207885..208097 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
DAX60_RS00980 (208385) 208385..208675 - 291 WP_000455790.1 HTH-type transcriptional regulator -
DAX60_RS00985 (209114) 209114..209824 + 711 WP_001528166.1 DUF3053 domain-containing protein -
DAX60_RS00990 (209874) 209874..210848 - 975 WP_001528209.1 glyoxylate/hydroxypyruvate reductase GhrB -
DAX60_RS00995 (211078) 211078..211740 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T207564 WP_000533909.1 NZ_CP077702:206317-206802 [Salmonella enterica subsp. enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T207564 NZ_CP103398:40043-40318 [Listeria innocua]
ATGAGTAAACATTTTCATGTGAGATTTGAAAAAGATGCTCAAAAAGTATTAAAAAAGATGGATCGATTTCAAGCGAAATT
GATTTTATCTTGGATTGAAAAGCATATCGAAGGATCAGATAATCCACGTCAACATGGTAAAAGTTTAGTTGGCAATCGTG
TAGGACAGTGGAGATATAGAGTAGGAGATTATCGCTTAATTGCAGAGATTCAAGATAATGAAGTGATAGTGTTAATTTTG
AACATCGGACACAGGAGAGATATTTACGATAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT207564 WP_000965886.1 NZ_CP077702:206042-206329 [Salmonella enterica subsp. enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT207564 NZ_CP103398:39825-40046 [Listeria innocua]
ATGACTACCATTACATTTCGAGTATCTGAACAAGAAAAGGCGTTTATTCAAGAAATGGCTAAGTTTAATGGTATATCTAT
TTCTGAACTCAGTCGCAAACAGATTATAGAAGGTTTAGAAGATCAAATTGATTTACAATCGTATGAGCGTGCTATAAAGG
CGCATCAGGTGAAAGATGAAAGTATTTCTTTTGATGAAATGAAAAAGGAACTTGATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References