Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
| Location | 19868..20421 | Replicon | plasmid pCFSAN058591_02 |
| Accession | NZ_CP077701 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058591 | ||
Toxin (Protein)
| Gene name | ccdB | Uniprot ID | A0A3R0G118 |
| Locus tag | DAY16_RS24465 | Protein ID | WP_058645035.1 |
| Coordinates | 19868..20182 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | ccdA | Uniprot ID | A0A6P1V7Y5 |
| Locus tag | DAY16_RS24470 | Protein ID | WP_025861853.1 |
| Coordinates | 20185..20421 (-) | Length | 79 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAY16_RS24430 (DAY16_024425) | 15207..15419 | - | 213 | Protein_19 | sprT domain-containing protein | - |
| DAY16_RS24435 (DAY16_024430) | 15499..15939 | - | 441 | Protein_20 | AAA family ATPase | - |
| DAY16_RS24440 (DAY16_024435) | 16054..16200 | - | 147 | WP_057394955.1 | colicin release lysis protein | - |
| DAY16_RS24445 (DAY16_024440) | 16284..16541 | - | 258 | WP_070794402.1 | bacteriocin immunity protein | - |
| DAY16_RS24450 (DAY16_024445) | 16544..18295 | - | 1752 | WP_058645033.1 | colicin-like bacteriocin tRNase domain-containing protein | - |
| DAY16_RS24455 (DAY16_024450) | 18760..19115 | - | 356 | Protein_24 | SprT-like domain-containing protein | - |
| DAY16_RS24820 | 19534..19647 | - | 114 | Protein_25 | XRE family transcriptional regulator | - |
| DAY16_RS24460 (DAY16_024455) | 19663..19827 | - | 165 | WP_165801018.1 | hypothetical protein | - |
| DAY16_RS24465 (DAY16_024460) | 19868..20182 | - | 315 | WP_058645035.1 | CcdB family protein | Toxin |
| DAY16_RS24470 (DAY16_024465) | 20185..20421 | - | 237 | WP_025861853.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
| DAY16_RS24475 (DAY16_024470) | 20530..20961 | - | 432 | WP_058645036.1 | hypothetical protein | - |
| DAY16_RS24480 (DAY16_024475) | 21768..22475 | - | 708 | WP_254891021.1 | RepA protein | - |
| DAY16_RS24485 (DAY16_024480) | 22936..23295 | - | 360 | WP_057517074.1 | helix-turn-helix transcriptional regulator | - |
| DAY16_RS24490 (DAY16_024485) | 23545..24000 | + | 456 | WP_058645037.1 | transcription termination/antitermination NusG family protein | - |
| DAY16_RS24495 (DAY16_024490) | 24072..24287 | + | 216 | WP_004178170.1 | hypothetical protein | - |
| DAY16_RS24500 (DAY16_024495) | 24292..24510 | + | 219 | WP_004178172.1 | hypothetical protein | - |
| DAY16_RS24825 | 24507..24629 | - | 123 | WP_254891022.1 | hypothetical protein | - |
| DAY16_RS24505 (DAY16_024500) | 24628..25338 | + | 711 | WP_058645038.1 | lytic transglycosylase domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | - | 1..26022 | 26022 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11542.39 Da Isoelectric Point: 5.8036
>T207563 WP_058645035.1 NZ_CP077701:c20182-19868 [Salmonella enterica subsp. enterica]
MQFTVYSNTGKSTVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AAFCDASPYRTEVKAAIDFLLDGI
MQFTVYSNTGKSTVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AAFCDASPYRTEVKAAIDFLLDGI
Download Length: 315 bp
>T207563 NZ_CP103396:1220-1564 [Levilactobacillus brevis]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATTTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGCCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGACTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATTTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGCCAAACAGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGACTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG
Antitoxin
Download Length: 79 a.a. Molecular weight: 8907.84 Da Isoelectric Point: 4.8040
>AT207563 WP_025861853.1 NZ_CP077701:c20421-20185 [Salmonella enterica subsp. enterica]
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF
Download Length: 237 bp
>AT207563 NZ_CP103396:963-1226 [Levilactobacillus brevis]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGCAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3R0G118 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V7Y5 |