Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 117008..117651 Replicon plasmid pCFSAN058591_01
Accession NZ_CP077700
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name vagD Uniprot ID A0A632GNP3
Locus tag DAY16_RS24240 Protein ID WP_001644958.1
Coordinates 117008..117424 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A5Z7X8E3
Locus tag DAY16_RS24245 Protein ID WP_001644959.1
Coordinates 117421..117651 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS24220 (DAY16_024215) 112734..113708 - 975 WP_001644948.1 ParB family protein -
DAY16_RS24225 (DAY16_024220) 113708..114913 - 1206 WP_001644949.1 AAA family ATPase -
DAY16_RS24230 (DAY16_024225) 115161..115781 + 621 WP_001644950.1 recombinase family protein -
DAY16_RS24235 (DAY16_024230) 115917..116612 + 696 WP_024153690.1 IS6 family transposase -
DAY16_RS24800 116666..116866 + 201 Protein_125 Lrp/AsnC family transcriptional regulator -
DAY16_RS24240 (DAY16_024235) 117008..117424 - 417 WP_001644958.1 type II toxin-antitoxin system VapC family toxin Toxin
DAY16_RS24245 (DAY16_024240) 117421..117651 - 231 WP_001644959.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DAY16_RS24250 (DAY16_024245) 118084..118347 + 264 WP_024153651.1 hypothetical protein -
DAY16_RS24255 (DAY16_024250) 118400..118789 - 390 Protein_129 IS3 family transposase -
DAY16_RS24260 (DAY16_024255) 118936..121746 - 2811 WP_070812003.1 autotransporter outer membrane beta-barrel domain-containing protein -
DAY16_RS24265 (DAY16_024260) 122067..122306 + 240 Protein_131 RNA 2'-phosphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroN 1..136494 136494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15078.48 Da        Isoelectric Point: 9.1880

>T207562 WP_001644958.1 NZ_CP077700:c117424-117008 [Salmonella enterica subsp. enterica]
VNKTYMLDTNICSFIMREQPKAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPNLVLEDWVK

Download         Length: 417 bp

>T207562 NZ_CP103352:c1377430-1376684 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTACCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCCTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCCTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8706.80 Da        Isoelectric Point: 4.4692

>AT207562 WP_001644959.1 NZ_CP077700:c117651-117421 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADADFLVEREDVVSDEGRFNL

Download         Length: 231 bp

>AT207562 NZ_CP103352:c1376684-1376514 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A632GNP3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7X8E3

References