Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4395508..4396289 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag DAY16_RS21460 Protein ID WP_000625912.1
Coordinates 4395508..4395999 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag DAY16_RS21465 Protein ID WP_001110450.1
Coordinates 4395996..4396289 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS21425 (4390919) 4390919..4391266 + 348 WP_000887832.1 divalent cation tolerance protein CutA -
DAY16_RS21430 (4391242) 4391242..4392945 + 1704 WP_000068889.1 protein-disulfide reductase DsbD -
DAY16_RS21435 (4392982) 4392982..4393557 + 576 WP_001188509.1 transcriptional regulator -
DAY16_RS21445 (4393828) 4393828..4393902 - 75 Protein_4222 helix-turn-helix domain-containing protein -
DAY16_RS21450 (4394282) 4394282..4394359 + 78 Protein_4223 porin family protein -
DAY16_RS21455 (4394459) 4394459..4395211 + 753 WP_070794150.1 non-specific acid phosphatase -
DAY16_RS21460 (4395508) 4395508..4395999 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
DAY16_RS21465 (4395996) 4395996..4396289 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
DAY16_RS24745 (4396606) 4396606..4396815 + 210 Protein_4227 hypothetical protein -
DAY16_RS21470 (4397079) 4397079..4397954 + 876 WP_000921676.1 AraC family transcriptional regulator -
DAY16_RS21475 (4397951) 4397951..4398238 + 288 WP_001269916.1 transcriptional regulator RtsB -
DAY16_RS24750 (4398231) 4398231..4398413 - 183 WP_001527266.1 ATP-binding cassette domain-containing protein -
DAY16_RS24755 (4398433) 4398433..4398532 + 100 Protein_4231 hypothetical protein -
DAY16_RS24760 (4398642) 4398642..4398776 + 135 Protein_4232 hypothetical protein -
DAY16_RS21485 (4399071) 4399071..4399976 - 906 WP_001268209.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T207559 WP_000625912.1 NZ_CP077699:c4395999-4395508 [Salmonella enterica subsp. enterica]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T207559 NZ_CP103351:571580-571930 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT207559 WP_001110450.1 NZ_CP077699:c4396289-4395996 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT207559 NZ_CP103351:571294-571575 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References