Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4255144..4255660 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag DAY16_RS20640 Protein ID WP_000220578.1
Coordinates 4255144..4255428 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag DAY16_RS20645 Protein ID WP_000212724.1
Coordinates 4255418..4255660 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS20625 (4250260) 4250260..4251912 + 1653 WP_000155035.1 alpha,alpha-phosphotrehalase -
DAY16_RS20630 (4252321) 4252321..4254459 + 2139 WP_000187815.1 anaerobic ribonucleoside-triphosphate reductase -
DAY16_RS20635 (4254676) 4254676..4255140 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAY16_RS20640 (4255144) 4255144..4255428 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAY16_RS20645 (4255418) 4255418..4255660 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAY16_RS20650 (4255738) 4255738..4257651 - 1914 WP_001212131.1 BglG family transcription antiterminator -
DAY16_RS20655 (4257668) 4257668..4258408 - 741 WP_000779263.1 KDGP aldolase family protein -
DAY16_RS20660 (4258405) 4258405..4259523 - 1119 WP_001139184.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAY16_RS20665 (4259507) 4259507..4260640 - 1134 WP_001636647.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T207558 WP_000220578.1 NZ_CP077699:c4255428-4255144 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207558 NZ_CP103350:1898999-1899175 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT207558 WP_000212724.1 NZ_CP077699:c4255660-4255418 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207558 NZ_CP103350:c1899213-1899116 [Bacillus subtilis]
GAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCG
CTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References