Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3563518..3564138 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAY16_RS17455 Protein ID WP_001280991.1
Coordinates 3563920..3564138 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAY16_RS17450 Protein ID WP_000344807.1
Coordinates 3563518..3563892 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS17440 (3558657) 3558657..3559850 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAY16_RS17445 (3559873) 3559873..3563022 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DAY16_RS17450 (3563518) 3563518..3563892 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAY16_RS17455 (3563920) 3563920..3564138 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAY16_RS17460 (3564317) 3564317..3564868 + 552 WP_001278786.1 maltose O-acetyltransferase -
DAY16_RS17465 (3564985) 3564985..3565455 + 471 WP_000136183.1 YlaC family protein -
DAY16_RS17470 (3565510) 3565510..3565650 - 141 WP_070794274.1 type B 50S ribosomal protein L36 -
DAY16_RS17475 (3565656) 3565656..3565916 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DAY16_RS17480 (3566141) 3566141..3567691 + 1551 WP_001642888.1 EAL domain-containing protein -
DAY16_RS17490 (3567922) 3567922..3568311 + 390 WP_000961285.1 MGMT family protein -
DAY16_RS17495 (3568344) 3568344..3568913 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207557 WP_001280991.1 NZ_CP077699:3563920-3564138 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207557 NZ_CP103350:1898999-1899175 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCATAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGATAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207557 WP_000344807.1 NZ_CP077699:3563518-3563892 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207557 NZ_CP103350:c1899058-1898958 [Bacillus subtilis]
GATTGTAAGAACCGTTAAAGATATGAGGAAAGCAACTATGATACCCACTTTCTCAAGCACTATGTACACCTCCTTTCCTA
TGACTCTATTATAACATAATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References