Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2180998..2181636 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Z7XAU3
Locus tag DAY16_RS10560 Protein ID WP_072209095.1
Coordinates 2181454..2181636 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5W1Z1L9
Locus tag DAY16_RS10555 Protein ID WP_058645062.1
Coordinates 2180998..2181411 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS10530 (2176363) 2176363..2176590 + 228 WP_058645057.1 hypothetical protein -
DAY16_RS10535 (2176669) 2176669..2178612 + 1944 WP_070810084.1 replication endonuclease -
DAY16_RS10540 (2178764) 2178764..2179045 + 282 WP_108451050.1 hypothetical protein -
DAY16_RS10545 (2179068) 2179068..2180204 + 1137 WP_259407462.1 DUF968 domain-containing protein -
DAY16_RS10550 (2180201) 2180201..2180854 + 654 WP_070804841.1 bacteriophage antitermination protein Q -
DAY16_RS10555 (2180998) 2180998..2181411 - 414 WP_058645062.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DAY16_RS10560 (2181454) 2181454..2181636 - 183 WP_072209095.1 type II toxin-antitoxin system HicA family toxin Toxin
DAY16_RS10565 (2182022) 2182022..2182534 + 513 WP_000259586.1 DUF1440 domain-containing protein -
DAY16_RS10570 (2183221) 2183221..2183577 + 357 WP_070809063.1 hypothetical protein -
DAY16_RS10575 (2183605) 2183605..2183790 - 186 WP_070809064.1 hypothetical protein -
DAY16_RS10580 (2184092) 2184092..2184310 + 219 WP_058645066.1 phage holin -
DAY16_RS10585 (2184288) 2184288..2184827 + 540 WP_070809065.1 lysozyme -
DAY16_RS10590 (2184928) 2184928..2185392 + 465 WP_070809066.1 lysis protein -
DAY16_RS10595 (2185424) 2185424..2185714 - 291 WP_070809067.1 Bor family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2164363..2209387 45024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6891.15 Da        Isoelectric Point: 10.8877

>T207556 WP_072209095.1 NZ_CP077699:c2181636-2181454 [Salmonella enterica subsp. enterica]
MKSSELIKLLESKGWTLERINGSHHHFSHPDFPVIITVPHPRKDIKPGTLNQILKKAKLK

Download         Length: 183 bp

>T207556 NZ_CP103350:c1322172-1321426 [Bacillus subtilis]
ATGGTTTTATTCTTTCAGATCATGGTCTGGTGCATCGTGGCCGGACTGGGGTTATACGTATATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGGAAAACTTGGTATTTGCTGTTTGTTCTAGGCGCTATGGTATACTGGA
CATATGAGCCCACTTCCCTATTTACCCACTGGGAACGGTATCTCATTGTCGCAGTCAGTTTTGCTTTGATTGATGCTTTT
ATCTTCTTAAGTGCATACGTCAAAAAACTGGCCGGCAGCGAGCTTGAAACAGACACAAGAGAAATTCTTGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAGCCGATCCATGTTTATTATG
GAAGTATAGATGCTTATGCTGAAGGTATTGATAAGCTGCTGAAAACCTATGCTGATAAAATGAACTTAACGGCTTCTCTT
TGCCACTATTCGACACAGGCTGATAAAGACCGGTTAACCGAGCATATGGATGATCCGGCAGATGTACAAACACGGCTCGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTACCATCGAGACACAGAACTATGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTATTTACGTCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15250.99 Da        Isoelectric Point: 4.5174

>AT207556 WP_058645062.1 NZ_CP077699:c2181411-2180998 [Salmonella enterica subsp. enterica]
MLYPAFIEVDKDGSASGWFPDVPGCIFAGSTIEETYADARSAICAHFEVLCDKGFDIPSPRSIEQHVAAEPDDYSNGRWL
YVDVNMDQFDGRAERINVTLPHRLLDRIDATVKQHPDYGSRSAFLAAAARNELQKSL

Download         Length: 414 bp

>AT207556 NZ_CP103350:c1321426-1321256 [Bacillus subtilis]
ATGGAACGTGCGTTTCAAAACAGATGCGAGCCCAGAGCGGCGAAGCCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z7XAU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5W1Z1L9

References