Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 1312794..1313439 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Z7XAV3
Locus tag DAY16_RS06325 Protein ID WP_070800844.1
Coordinates 1313257..1313439 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A5Z7XCZ9
Locus tag DAY16_RS06320 Protein ID WP_058645148.1
Coordinates 1312794..1313228 (-) Length 145 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS06305 (1307895) 1307895..1308638 + 744 WP_024154110.1 C40 family peptidase -
DAY16_RS06310 (1308536) 1308536..1309243 + 708 WP_031604554.1 tail assembly protein -
DAY16_RS06315 (1309314) 1309314..1312727 + 3414 WP_259407461.1 host specificity protein J -
DAY16_RS06320 (1312794) 1312794..1313228 - 435 WP_058645148.1 transcriptional regulator Antitoxin
DAY16_RS06325 (1313257) 1313257..1313439 - 183 WP_070800844.1 type II toxin-antitoxin system HicA family toxin Toxin
DAY16_RS06330 (1313528) 1313528..1314409 + 882 WP_070794208.1 prophage tail fiber N-terminal domain-containing protein -
DAY16_RS06335 (1314420) 1314420..1315013 + 594 WP_070804872.1 DUF4376 domain-containing protein -
DAY16_RS06340 (1315121) 1315121..1315495 + 375 WP_058645172.1 DUF1353 domain-containing protein -
DAY16_RS06345 (1315772) 1315772..1316035 - 264 WP_058645171.1 hypothetical protein -
DAY16_RS06350 (1316035) 1316035..1316877 - 843 WP_259407089.1 S-type pyocin domain-containing protein -
DAY16_RS24580 (1316893) 1316893..1318149 - 1257 WP_259407090.1 colicin-like bacteriocin tRNase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1277730..1315013 37283


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6892.08 Da        Isoelectric Point: 10.4804

>T207547 WP_070800844.1 NZ_CP077699:c1313439-1313257 [Salmonella enterica subsp. enterica]
MKYNEFRRWLIQQGAKFINAPDGGSHQRVILNGKESVFPCHGAKEMPEPLRKKILKDLGL

Download         Length: 183 bp

>T207547 NZ_CP103345:c659164-658880 [Brucella anthropi]
ATGTCCCAGTCAGTTGAATTCATGCTCTTGAAAACACAATGGTATCTGTCTCGCAATTGGATCAGAGCGAAATGGAAAAC
TGGTTCAAACTCAATTGAAACTCAACACTTGCATTTAGAATTCTTCTTGTCGGCCAAGGTCTTCCCTACCAAGGCAGATC
GCTTGATGGCAATCGGCGAATTCAACGGTCAGATCATTATCGTCGTCGTCTTCAAGCCGATTGGTTCGGAAGCCCTCTCC
GTTATCTCCATGCGTCCAGCAAGCCAAAAGGAAAGGAAGCTATGA

Antitoxin


Download         Length: 145 a.a.        Molecular weight: 15777.18 Da        Isoelectric Point: 4.5833

>AT207547 WP_058645148.1 NZ_CP077699:c1313228-1312794 [Salmonella enterica subsp. enterica]
MFNYAVKPEYDPATESWVVTCRDLPLFNSVSFSIDDALLEAVDGAIVALSIEIDARRPVPIASQPEEGEYVIHLPVLVVM
KAALHNAMISTGTRKSDLARTMGMKGPQIDRLLDVCHSSKVETVELALQQLNRTVQISVDNVAV

Download         Length: 435 bp

>AT207547 NZ_CP103345:c658880-658566 [Brucella anthropi]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGCAATCCAGAAGATGATCGCAAGTGATCC
TGATGCGCCAGAAGCCACCGATGAACAACTTGCCAAGGCAAAACCCTTCAAAGAAGCCCTCCCGGAAATGGCCGCCAAGA
TGGAGAAGGCCATTCGGGGCCGACCGCGTATCGACGATCCCAAGACACCGGTTACGATCCGGCTCGATCAGGATGTGGTT
CAACGCTTCAAGGCTACTGGCAAAGGTTGGCAGAGCCGCATGAATGAGGCTCTGCGCAAGGCTGTTGGCCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z7XAV3

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z7XCZ9

References