Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 937769..938429 Replicon chromosome
Accession NZ_CP077699
Organism Salmonella enterica subsp. enterica strain CFSAN058591

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Y0E4E4
Locus tag DAY16_RS04510 Protein ID WP_000244757.1
Coordinates 938016..938429 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAY16_RS04505 Protein ID WP_000351186.1
Coordinates 937769..938035 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAY16_RS04485 (933697) 933697..935130 - 1434 WP_001230152.1 6-phospho-beta-glucosidase BglA -
DAY16_RS04490 (935289) 935289..935600 + 312 WP_058344418.1 N(4)-acetylcytidine aminohydrolase -
DAY16_RS04495 (935764) 935764..936423 + 660 WP_000250289.1 hemolysin III family protein -
DAY16_RS04500 (936539) 936539..937519 - 981 WP_000874170.1 tRNA-modifying protein YgfZ -
DAY16_RS04505 (937769) 937769..938035 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAY16_RS04510 (938016) 938016..938429 + 414 WP_000244757.1 protein YgfX Toxin
DAY16_RS04515 (938482) 938482..939003 - 522 WP_001055885.1 flavodoxin FldB -
DAY16_RS04520 (939116) 939116..940012 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
DAY16_RS04525 (940036) 940036..940749 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAY16_RS04530 (940755) 940755..942488 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16282.29 Da        Isoelectric Point: 11.1741

>T207546 WP_000244757.1 NZ_CP077699:938016-938429 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISRQH

Download         Length: 414 bp

>T207546 NZ_CP103341:c5121-4801 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATCTTTACCAAGCAAATCAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAACA
AGATCTATTGGTTCAGCCAGATAAAGGTGACTTAATCAAGAATGGCGGTGGCATTCGAAAAGTACGTTGTGCTCAAGGGA
ATAAAGGCAAAAGTGGCGGTATCAGAGTAATTTACTATTGGGTAAATGAGGATGATCAAATCTTTTTCTTGGTGGCTTAT
CCAAAATCTGTAAAAGATAATCTAACGGATAAAGAAACCGCCATTCTGCGCCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207546 WP_000351186.1 NZ_CP077699:937769-938035 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207546 NZ_CP103341:c4808-4536 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTAGTTGCTTCGATTAAAGAAGCAGGAGCAATCAAGCGCAAAGAGATCCAAGCTAG
TCGAACGACCGAACTTAAATTACCAGATATTAAGGAAGTGCGAGAAAAAACTGGTTTAAGTCAAAGCGAATTTGCAGCAC
GTCTCCACATTAGCCATCGTACTCTGCAAAACTGGGAACAAGGCCGACGCTATCCAACAGGACCAGCAGCAACATTGATT
CGAATTTTAGATGCACATCCTAGTCTTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Y0E4E4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References