Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1348..1901 Replicon plasmid pCFSAN058598_02
Accession NZ_CP077698
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3R0G118
Locus tag DAX72_RS24135 Protein ID WP_058645035.1
Coordinates 1348..1662 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A6P1V7Y5
Locus tag DAX72_RS24140 Protein ID WP_025861853.1
Coordinates 1665..1901 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS24125 (DAX72_024125) 240..595 - 356 Protein_0 SprT-like domain-containing protein -
DAX72_RS24695 1014..1127 - 114 Protein_1 XRE family transcriptional regulator -
DAX72_RS24130 (DAX72_024130) 1143..1307 - 165 WP_165801018.1 hypothetical protein -
DAX72_RS24135 (DAX72_024135) 1348..1662 - 315 WP_058645035.1 CcdB family protein Toxin
DAX72_RS24140 (DAX72_024140) 1665..1901 - 237 WP_025861853.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
DAX72_RS24145 (DAX72_024145) 2010..2441 - 432 WP_058645036.1 hypothetical protein -
DAX72_RS24150 (DAX72_024150) 3248..3955 - 708 WP_254891021.1 RepA protein -
DAX72_RS24155 (DAX72_024155) 4416..4775 - 360 WP_057517074.1 helix-turn-helix transcriptional regulator -
DAX72_RS24160 (DAX72_024160) 5025..5480 + 456 WP_058645037.1 transcription termination/antitermination NusG family protein -
DAX72_RS24165 (DAX72_024165) 5552..5767 + 216 WP_004178170.1 hypothetical protein -
DAX72_RS24170 (DAX72_024170) 5772..5990 + 219 WP_004178172.1 hypothetical protein -
DAX72_RS24175 (DAX72_024175) 6108..6818 + 711 WP_058645038.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..26030 26030


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11542.39 Da        Isoelectric Point: 5.8036

>T207544 WP_058645035.1 NZ_CP077698:c1662-1348 [Salmonella enterica subsp. enterica]
MQFTVYSNTGKSTVYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPGSTRPERLVPLVRLTDDKEYAVMTHEMASIPARSLG
AAFCDASPYRTEVKAAIDFLLDGI

Download         Length: 315 bp

>T207544 NZ_CP103340:c18719-18363 [Acinetobacter baumannii]
ATGTGGACAGTCATTACGACAGATCTATTTAATCAGTGGCTTGAACAGCAAGAAGAATCAACACAAGAGAAGGTTCTGGC
TGCCCTGGTTGTTCTACAGCAGCAAGGACCAAGTTTAGGCCGCCCTTTAGTAGATACCGTCTATGACTCTAAATTTACCA
ACATGAAAGAGCTCCGTGTTCAACATCGAGGTAAACCACTGAGAGCTTTCTTCGCATTCGATCCATTGCGTCAGGCAATT
GTGCTATGTATTGCTGATAAAGGCGGTAAAAAACGTTTTTATAAAGACATGCTGGATATTGCAGATGAACAATACCAACT
TCATCTCACCACCTTAGGAGATAAATCTAATGGCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8907.84 Da        Isoelectric Point: 4.8040

>AT207544 WP_025861853.1 NZ_CP077698:c1901-1665 [Salmonella enterica subsp. enterica]
MATTQRATQSVTMTVERALLSRAREAGINLSATLTAALDAELRQYEAKKWQEENNEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT207544 NZ_CP103340:c18370-18068 [Acinetobacter baumannii]
ATGGCTAAGACTCTGCAAGAATTGTTAGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATGGCAGATGAATT
ACTGCTAGAAAATCAGCTTCATCTTATTCGTGAAGAACTCGAAATTTCTCAAAAAGAGCTTGCTGAAACTTTGGGAATAA
AACAACCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAGGCAATG
GGAGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R0G118

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V7Y5

References