Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 88720..89375 | Replicon | plasmid pCFSAN058598_01 |
| Accession | NZ_CP077697 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058598 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A2A6D4W4 |
| Locus tag | DAX72_RS24080 | Protein ID | WP_023972453.1 |
| Coordinates | 88947..89375 (+) | Length | 143 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A2A6D545 |
| Locus tag | DAX72_RS24075 | Protein ID | WP_023972452.1 |
| Coordinates | 88720..88950 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX72_RS24050 (84962) | 84962..85537 | - | 576 | WP_031233190.1 | PIN domain-containing protein | - |
| DAX72_RS24055 (85537) | 85537..85998 | - | 462 | WP_023972447.1 | helix-turn-helix domain-containing protein | - |
| DAX72_RS24690 (86196) | 86196..86291 | - | 96 | Protein_91 | malate dehydrogenase | - |
| DAX72_RS24060 (86307) | 86307..87083 | - | 777 | Protein_92 | site-specific integrase | - |
| DAX72_RS24065 (87080) | 87080..87787 | - | 708 | WP_023972450.1 | hypothetical protein | - |
| DAX72_RS24070 (87831) | 87831..88145 | - | 315 | WP_139148288.1 | hypothetical protein | - |
| DAX72_RS24075 (88720) | 88720..88950 | + | 231 | WP_023972452.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| DAX72_RS24080 (88947) | 88947..89375 | + | 429 | WP_023972453.1 | PIN domain-containing protein | Toxin |
| DAX72_RS24085 (89416) | 89416..90294 | - | 879 | WP_023972454.1 | restriction endonuclease | - |
| DAX72_RS24090 (90555) | 90555..91169 | + | 615 | WP_023972455.1 | DNA-binding protein | - |
| DAX72_RS24095 (91546) | 91546..92058 | + | 513 | WP_023972457.1 | hypothetical protein | - |
| DAX72_RS24100 (92083) | 92083..92373 | + | 291 | WP_023972458.1 | hypothetical protein | - |
| DAX72_RS24105 (92370) | 92370..92633 | + | 264 | WP_023972459.1 | hypothetical protein | - |
| DAX72_RS24110 (92719) | 92719..93266 | - | 548 | Protein_102 | N-acetyltransferase | - |
| DAX72_RS24115 (93277) | 93277..93519 | - | 243 | WP_023972461.1 | YjhX family toxin | - |
| DAX72_RS24120 (93733) | 93733..94101 | + | 369 | Protein_104 | DUF302 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..94857 | 94857 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 143 a.a. Molecular weight: 15583.12 Da Isoelectric Point: 9.9442
>T207543 WP_023972453.1 NZ_CP077697:88947-89375 [Salmonella enterica subsp. enterica]
MKQPRTKTYMLDTNICSFIMREQPEKVLKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDTILP
WDKAAVDATTDIKAALAAAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLKLEDWVK
MKQPRTKTYMLDTNICSFIMREQPEKVLKRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHAQLVDAFCARLDTILP
WDKAAVDATTDIKAALAAAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLKLEDWVK
Download Length: 429 bp
>T207543 NZ_CP103338:c3213006-3212617 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAAATATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCACGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8889.94 Da Isoelectric Point: 4.3331
>AT207543 WP_023972452.1 NZ_CP077697:88720-88950 [Salmonella enterica subsp. enterica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWESFFREEKADADFMAEREDVVSDEGRFEL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWESFFREEKADADFMAEREDVVSDEGRFEL
Download Length: 231 bp
>AT207543 NZ_CP103338:c3213270-3213013 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A6D4W4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2A6D545 |