Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 84962..85998 | Replicon | plasmid pCFSAN058598_01 |
| Accession | NZ_CP077697 | ||
| Organism | Salmonella enterica subsp. enterica strain CFSAN058598 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | DAX72_RS24050 | Protein ID | WP_031233190.1 |
| Coordinates | 84962..85537 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A2A6D4K4 |
| Locus tag | DAX72_RS24055 | Protein ID | WP_023972447.1 |
| Coordinates | 85537..85998 (-) | Length | 154 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DAX72_RS24025 (80204) | 80204..81577 | - | 1374 | WP_023972442.1 | RES family NAD+ phosphorylase | - |
| DAX72_RS24030 (81627) | 81627..81950 | - | 324 | WP_023972443.1 | hypothetical protein | - |
| DAX72_RS24035 (81947) | 81947..82384 | - | 438 | WP_000843283.1 | hypothetical protein | - |
| DAX72_RS24040 (82384) | 82384..83415 | - | 1032 | WP_023972444.1 | ParB/RepB/Spo0J family partition protein | - |
| DAX72_RS24045 (83415) | 83415..84281 | - | 867 | WP_023972445.1 | AAA family ATPase | - |
| DAX72_RS24050 (84962) | 84962..85537 | - | 576 | WP_031233190.1 | PIN domain-containing protein | Toxin |
| DAX72_RS24055 (85537) | 85537..85998 | - | 462 | WP_023972447.1 | helix-turn-helix domain-containing protein | Antitoxin |
| DAX72_RS24690 (86196) | 86196..86291 | - | 96 | Protein_91 | malate dehydrogenase | - |
| DAX72_RS24060 (86307) | 86307..87083 | - | 777 | Protein_92 | site-specific integrase | - |
| DAX72_RS24065 (87080) | 87080..87787 | - | 708 | WP_023972450.1 | hypothetical protein | - |
| DAX72_RS24070 (87831) | 87831..88145 | - | 315 | WP_139148288.1 | hypothetical protein | - |
| DAX72_RS24075 (88720) | 88720..88950 | + | 231 | WP_023972452.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| DAX72_RS24080 (88947) | 88947..89375 | + | 429 | WP_023972453.1 | PIN domain-containing protein | - |
| DAX72_RS24085 (89416) | 89416..90294 | - | 879 | WP_023972454.1 | restriction endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..94857 | 94857 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21416.70 Da Isoelectric Point: 4.7272
>T207542 WP_031233190.1 NZ_CP077697:c85537-84962 [Salmonella enterica subsp. enterica]
MNHTPYPVVLDACVLYPSFLRDLLIRLGLTGLYQPKWSASIENEWQRNLLANRTDLTEEQIKRTATLMNKAVPDALVTGF
EPLIDSIDLPDVDDRHVAAAAVRSNAEIIVTLNLKDFPAPALDAFGIEALHPDDFVMDLFDLNRALVLSAVTTQRSSLRK
PPVSVDEYLEALLRQGMAQTVKELSKYRMLI
MNHTPYPVVLDACVLYPSFLRDLLIRLGLTGLYQPKWSASIENEWQRNLLANRTDLTEEQIKRTATLMNKAVPDALVTGF
EPLIDSIDLPDVDDRHVAAAAVRSNAEIIVTLNLKDFPAPALDAFGIEALHPDDFVMDLFDLNRALVLSAVTTQRSSLRK
PPVSVDEYLEALLRQGMAQTVKELSKYRMLI
Download Length: 576 bp
>T207542 NZ_CP103338:c1836116-1835760 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 154 a.a. Molecular weight: 16936.43 Da Isoelectric Point: 5.5842
>AT207542 WP_023972447.1 NZ_CP077697:c85998-85537 [Salmonella enterica subsp. enterica]
MTNSILDSLSLPAKGEIEAAVRGQRELAAYLSTKMETQKISIQDADNVTHQIELPTSSLTLLMSILGELALGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRVLFADLMKYKDQRDSDSNIAMQELADLSQELGLY
MTNSILDSLSLPAKGEIEAAVRGQRELAAYLSTKMETQKISIQDADNVTHQIELPTSSLTLLMSILGELALGNAVQVVPV
HAELTTQEAANILNVSRPHMVKLLEEGKLPFHKTGRHRRVLFADLMKYKDQRDSDSNIAMQELADLSQELGLY
Download Length: 462 bp
>AT207542 NZ_CP103338:c1835767-1835465 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|