207539

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4104912..4105572 Replicon chromosome
Accession NZ_CP077696
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I1G658
Locus tag DAX72_RS20235 Protein ID WP_001727955.1
Coordinates 4104912..4105325 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag DAX72_RS20240 Protein ID WP_000351186.1
Coordinates 4105306..4105572 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS20215 (4100853) 4100853..4102586 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
DAX72_RS20220 (4102592) 4102592..4103305 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DAX72_RS20225 (4103329) 4103329..4104225 - 897 WP_108411765.1 site-specific tyrosine recombinase XerD -
DAX72_RS20230 (4104338) 4104338..4104859 + 522 WP_001055885.1 flavodoxin FldB -
DAX72_RS20235 (4104912) 4104912..4105325 - 414 WP_001727955.1 protein YgfX Toxin
DAX72_RS20240 (4105306) 4105306..4105572 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
DAX72_RS20245 (4105822) 4105822..4106802 + 981 WP_000874169.1 tRNA-modifying protein YgfZ -
DAX72_RS20250 (4106918) 4106918..4107577 - 660 WP_000250289.1 hemolysin III family protein -
DAX72_RS20255 (4107741) 4107741..4108052 - 312 WP_023217488.1 N(4)-acetylcytidine aminohydrolase -
DAX72_RS20260 (4108211) 4108211..4109644 + 1434 WP_023217487.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16201.18 Da        Isoelectric Point: 10.7537

>T207539 WP_001727955.1 NZ_CP077696:c4105325-4104912 [Salmonella enterica subsp. enterica]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T207539 NZ_CP103332:2265-2540 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGTCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT207539 WP_000351186.1 NZ_CP077696:c4105572-4105306 [Salmonella enterica subsp. enterica]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207539 NZ_CP103332:1981-2265 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1G658

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References