Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3489999..3490619 Replicon chromosome
Accession NZ_CP077696
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag DAX72_RS17220 Protein ID WP_001280991.1
Coordinates 3490401..3490619 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag DAX72_RS17215 Protein ID WP_000344807.1
Coordinates 3489999..3490373 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS17205 (3485138) 3485138..3486331 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
DAX72_RS17210 (3486354) 3486354..3489503 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
DAX72_RS17215 (3489999) 3489999..3490373 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
DAX72_RS17220 (3490401) 3490401..3490619 + 219 WP_001280991.1 HHA domain-containing protein Toxin
DAX72_RS17225 (3490798) 3490798..3491349 + 552 WP_001278791.1 maltose O-acetyltransferase -
DAX72_RS17230 (3491467) 3491467..3491937 + 471 WP_000136183.1 YlaC family protein -
DAX72_RS17235 (3491993) 3491993..3492133 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
DAX72_RS17240 (3492139) 3492139..3492399 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
DAX72_RS17245 (3492624) 3492624..3494174 + 1551 WP_023230872.1 EAL domain-containing protein -
DAX72_RS17255 (3494405) 3494405..3494794 + 390 WP_023230873.1 MGMT family protein -
DAX72_RS17260 (3494827) 3494827..3495396 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T207538 WP_001280991.1 NZ_CP077696:3490401-3490619 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T207538 NZ_CP103331:c74811-74662 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT207538 WP_000344807.1 NZ_CP077696:3489999-3490373 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207538 NZ_CP103331:74855-74916 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References