Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3489999..3490619 | Replicon | chromosome |
Accession | NZ_CP077696 | ||
Organism | Salmonella enterica subsp. enterica strain CFSAN058598 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | V1H8E6 |
Locus tag | DAX72_RS17220 | Protein ID | WP_001280991.1 |
Coordinates | 3490401..3490619 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | V1H4V6 |
Locus tag | DAX72_RS17215 | Protein ID | WP_000344807.1 |
Coordinates | 3489999..3490373 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DAX72_RS17205 (3485138) | 3485138..3486331 | + | 1194 | WP_001039202.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
DAX72_RS17210 (3486354) | 3486354..3489503 | + | 3150 | WP_001132508.1 | efflux RND transporter permease AcrB | - |
DAX72_RS17215 (3489999) | 3489999..3490373 | + | 375 | WP_000344807.1 | Hha toxicity modulator TomB | Antitoxin |
DAX72_RS17220 (3490401) | 3490401..3490619 | + | 219 | WP_001280991.1 | HHA domain-containing protein | Toxin |
DAX72_RS17225 (3490798) | 3490798..3491349 | + | 552 | WP_001278791.1 | maltose O-acetyltransferase | - |
DAX72_RS17230 (3491467) | 3491467..3491937 | + | 471 | WP_000136183.1 | YlaC family protein | - |
DAX72_RS17235 (3491993) | 3491993..3492133 | - | 141 | WP_001197749.1 | type B 50S ribosomal protein L36 | - |
DAX72_RS17240 (3492139) | 3492139..3492399 | - | 261 | WP_000801415.1 | type B 50S ribosomal protein L31 | - |
DAX72_RS17245 (3492624) | 3492624..3494174 | + | 1551 | WP_023230872.1 | EAL domain-containing protein | - |
DAX72_RS17255 (3494405) | 3494405..3494794 | + | 390 | WP_023230873.1 | MGMT family protein | - |
DAX72_RS17260 (3494827) | 3494827..3495396 | - | 570 | WP_000779801.1 | YbaY family lipoprotein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8613.97 Da Isoelectric Point: 8.9008
>T207538 WP_001280991.1 NZ_CP077696:3490401-3490619 [Salmonella enterica subsp. enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T207538 NZ_CP103331:c74811-74662 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14453.27 Da Isoelectric Point: 5.1444
>AT207538 WP_000344807.1 NZ_CP077696:3489999-3490373 [Salmonella enterica subsp. enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC
Download Length: 375 bp
>AT207538 NZ_CP103331:74855-74916 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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