Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 744931..745447 Replicon chromosome
Accession NZ_CP077696
Organism Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)


Gene name relE Uniprot ID A0A5J2LRU5
Locus tag DAX72_RS03495 Protein ID WP_001609934.1
Coordinates 745163..745447 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2A6DDA6
Locus tag DAX72_RS03490 Protein ID WP_023972421.1
Coordinates 744931..745173 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAX72_RS03470 (739951) 739951..741084 + 1134 WP_001609909.1 amidohydrolase/deacetylase family metallohydrolase -
DAX72_RS03475 (741068) 741068..742186 + 1119 WP_001139182.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
DAX72_RS03480 (742183) 742183..742923 + 741 WP_023229489.1 KDGP aldolase family protein -
DAX72_RS03485 (742940) 742940..744853 + 1914 WP_001609931.1 BglG family transcription antiterminator -
DAX72_RS03490 (744931) 744931..745173 + 243 WP_023972421.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DAX72_RS03495 (745163) 745163..745447 + 285 WP_001609934.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DAX72_RS03500 (745451) 745451..745915 - 465 WP_017465840.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
DAX72_RS03505 (746132) 746132..748270 - 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
DAX72_RS03510 (748679) 748679..750331 - 1653 WP_023212814.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10859.66 Da        Isoelectric Point: 9.3941

>T207526 WP_001609934.1 NZ_CP077696:745163-745447 [Salmonella enterica subsp. enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSACLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T207526 NZ_CP103329:1104243-1104554 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8993.40 Da        Isoelectric Point: 5.0651

>AT207526 WP_023972421.1 NZ_CP077696:744931-745173 [Salmonella enterica subsp. enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPMKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT207526 NZ_CP103329:1104551-1104970 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J2LRU5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A6DDA6

References