Detailed information of TA system TA207525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 606769..607550
• Replicon: chromosome
• Accession: NZ_CP077696
• Organism: Salmonella enterica subsp. enterica strain CFSAN058598

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A3V8KWJ7
• Locus tag: DAX72_RS02780
• Protein ID: WP_001609688.1
• Coordinates: 607059..607550 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3V4SIN7
• Locus tag: DAX72_RS02775
• Protein ID: WP_001110453.1
• Coordinates: 606769..607062 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DAX72_RS02755 (603068)	603068..603973	+	906	WP_001268209.1	YjiK family protein	-
DAX72_RS24320 (604268)	604268..604402	-	135	Protein_543	hypothetical protein	-
DAX72_RS24325 (604512)	604512..604611	-	100	Protein_544	hypothetical protein	-
DAX72_RS24330 (604631)	604631..604813	+	183	WP_001527266.1	ATP-binding cassette domain-containing protein	-
DAX72_RS02765 (604806)	604806..605093	-	288	WP_001269916.1	transcriptional regulator RtsB	-
DAX72_RS02770 (605090)	605090..605965	-	876	WP_000921676.1	AraC family transcriptional regulator	-
DAX72_RS24335 (606229)	606229..606451	-	223	Protein_548	hypothetical protein	-
DAX72_RS02775 (606769)	606769..607062	+	294	WP_001110453.1	DUF1778 domain-containing protein	Antitoxin
DAX72_RS02780 (607059)	607059..607550	+	492	WP_001609688.1	GNAT family N-acetyltransferase	Toxin
DAX72_RS02785 (607765)	607765..608013	+	249	Protein_551	IS481 family transposase	-
DAX72_RS02790 (608288)	608288..608515	-	228	WP_001112992.1	hypothetical protein	-
DAX72_RS02795 (609108)	609108..609392	+	285	WP_192917775.1	PapB/FocB family fimbrial expression transcriptional regulator	-
DAX72_RS02800 (609427)	609427..609966	+	540	WP_000721295.1	type 1 fimbrial protein	-
DAX72_RS02805 (609976)	609976..612414	+	2439	WP_001014136.1	F4 (K88) fimbrial usher FaeD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeC / faeD / faeE / faeF / faeH / faeI	604806..620055	15249

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17664.46 Da
• Isoelectric Point: 7.2655

>T207525 WP_001609688.1 NZ_CP077696:607059-607550 [Salmonella enterica subsp. enterica]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVEETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T207525 NZ_CP103329:1037992-1038327 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10948.57 Da
• Isoelectric Point: 9.8590

>AT207525 WP_001110453.1 NZ_CP077696:606769-607062 [Salmonella enterica subsp. enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT207525 NZ_CP103329:1037744-1037992 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A3V8KWJ7

Antitoxin

• AlphaFold DB: A0A3V4SIN7